Mechanotransduction in tumor dynamics modeling Blanco Besteiro, Beatriz Melchor Rodríguez, Juan Manuel Palma Guerrero, Roberto Soler Vizcaino, Juan Segundo Rus Carlborg, Guillermo Computational mechanics LIUS Mechanotherapy Mechanotransduction Tumor dynamics Mechanotherapy is a groundbreaking approach to impact carcinogenesis. Cells sense and respond to mechanical stimuli, trans-lating them into biochemical signals in a process known as mechanotransduction. The impact of stress on tumor growth has been studied in the last three decades, and many papers highlight the role of mechanics as a critical self-inducer of tumor fate at the in vitro and in vivo biological levels. Meanwhile, mathematical models attempt to determine laws to reproduce tumor dynamics. This review discusses biological mechanotransduction mechanisms and mathematical-biomechanical models together. The aim is to provide a common framework for the different approaches that have emerged in the literature from the perspective of tumor avascularity and to provide insight into emerging mechanotherapies that have attracted interest in recent years. 2023-03-30T08:55:28Z 2023-03-30T08:55:28Z 2023-02-15 journal article B. Blanco... [et al.]. Mechanotransduction in tumor dynamics modeling, Physics of Life Reviews, Volume 44, 2023, Pages 279-301, ISSN 1571-0645, [https://doi.org/10.1016/j.plrev.2023.01.017] https://hdl.handle.net/10481/80942 10.1016/j.plrev.2023.01.017 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier