Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds Rojas García, Alejandro Fernández Ochoa, Álvaro Cádiz Gurrea, María de la Luz Arráez Román, David Segura Carretero, Antonio Neurodegeneration Plant by-products Phenolic compounds Neuroprotection Oxidative stress Protein aggregation Neuroinflammation Mitochondrial dysfunction AChE Neurodegenerative diseases are known for their wide range of harmful conditions related to progressive cell damage, nervous system connections and neuronal death. These pathologies promote the loss of essential motor and cognitive functions, such as mobility, learning and sensation. Neurodegeneration affects millions of people worldwide, and no integral cure has been created yet. Here, bioactive compounds have been proven to exert numerous beneficial effects due to their remarkable bioactivity, so they could be considered as great options for the development of new neuroprotective strategies. Phenolic bioactives have been reported to be found in edible part of plants; however, over the last years, a large amount of research has focused on the phenolic richness that plant by-products possess, which sometimes even exceeds the content in the pulp. Thus, their possible application as an emergent neuroprotective technique could also be considered as an optimal strategy to revalorize these agricultural residues (those originated from plant processing). This review aims to summarize main triggers of neurodegeneration, revise the state of the art in plant extracts and their role in avoiding neurodegeneration and discuss how their main phenolic compounds could exert their neuroprotective effects. For this purpose, a diverse search of studies has been conducted, gathering a large number of papers where by-products were used as strong sources of phenolic compounds for their neuroprotective properties. Finally, although a lack of investigation is quite remarkable and greatly limits the use of these compounds, phenolics remain attractive for research into new multifactorial anti-neurodegenerative nutraceuticals. 2023-03-22T11:01:03Z 2023-03-22T11:01:03Z 2023-01-14 journal article Rojas-García, A... [et al.]. Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds. Nutrients 2023, 15, 449. [https://doi.org/10.3390/nu15020449] https://hdl.handle.net/10481/80746 10.3390/nu15020449 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI