Iron-copper oxide nanoparticles supported on reduced graphene oxide for the degradation of cyclophosphamide by photo-Fenton reaction Pérez Poyatos, Lorena T. Pastrana Martínez, Luisa María Morales Torres, Sergio Sánchez Moreno, Paola Bramini, Mattia Maldonado Hodar, Francisco José Bimetallic catalysts Cyclophosphamide PhotoFenton Heterogeneous catalysis Reduced graphene oxide Supplementary data associated with this article can be found in the online version at doi:10.1016/j.cattod.2023.01.017 This work was financially supported by the FEDER/Junta de Andalucía- Consejería de Transformación Económica, Industria, Conocimiento y Universidades/B-RNM-486-UGR20 and project PCI2020–112045 from MCIN/AEI/10.13039/501100011033 and European Union Next Generation EU/PRTR, as part of the PRIMA Programme (Nano4Fresh project). S.M.T. (RYC-2019–026634-I), L.M.P.M. (RYC-2016–19347) and M.B. (RYC2019–027692-I) acknowledge the MICIN/AEI/10.13039/501100011033 and the European Social Found (FSE) “El FSE invierte en tu futuro” for Ramón y Cajal research contracts. P.S.M. acknowledges Ministerio de Ciencia e innovación y la Agencia Estatal de Investigación a través del programa Juan de la Cierva Incorporación (IJC2018–036305-I). Funding for open access charge: Universidad de Granada / CBUA Bimetallic (Fe-Cu) and reduced graphene oxide (rGO)/FeCu catalysts at 0.2% wt. were developed by a co-precipitation method, modifying the Fe-Cu molar proportions (i.e., Fe40Cu60, Fe20Cu80 and Fe10Cu90) and tested for the degradation of the cytostatic drug, cyclophosphamide (CP) in aqueous solution using the photo-Fenton process (UV-Vis). Physicochemical characterization was carried out by complementary techniques (gas adsorption, SEM, TEM, XRD, XPS) and results were correlated with the catalytic performance. The effect of pH on the degradation of the contaminant and the catalyst stability (metal leaching) were studied. The results point out the synergetic effect of the rGO/FeCu catalysts in comparison to the monometallic catalysts or without carbonaceous material. The best performance was achieved with the rGO/Fe10Cu90 catalyst achieving 82% of CP degradation at natural pH regarding 87% obtained under acid conditions (pH 3). This fact avoids the usual acidification of the solutions during Fenton-like processes and prevent the metal leaching, increasing the stability of catalysts, as demonstrated after consecutive degradation cycles, maintaining efficiency above 75%. Cytotoxicity tests certificated the low toxicity of the by-product derived from the photo-Fenton process. 2023-03-09T13:35:14Z 2023-03-09T13:35:14Z 2023-01-23 journal article L.T. Pérez-Poyatos, Catalysis Today, [https://doi.org/10.1016/j.cattod.2023.01.017] https://hdl.handle.net/10481/80501 10.1016/j.cattod.2023.01.017 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier