Influence of Gestational Diabetes and Pregestational Maternal BMI on the Brain of Six-Year-Old Offspring Manuello, Jordi Verdejo Román, Juan Torres Espínola, Francisco Escudero Marín, Mireia Catena Martínez, Andrés Campoy Folgoso, Cristina Body mass index Brain structure Gestational diabetes Transgenerational effects Background: Gestational diabetes (GD) and maternal excess weight are common pregnancy conditions that increase the risk of future complications for both the mother and her offspring. Their consequences on neurodevelopment are widely described in the literature, but less is known concerning the potential transgenerational influence on the brain structure. Methods: We used a combination of support vectors machine and hierarchical clustering to investigate the potential presence of anatomical brain differences in a sample of 109 children aged six years, born to mothers with overweight or obesity, or to mothers diagnosed with GD during pregnancy. Results: Significant effects are visible in the brain of children born to mothers with GD associated with pregestational excess weight, especially overweight instead of obesity. No differences in children's brain were observed when considering those born to normal-weight mothers. Conclusions: Our study highlights the need for clinical attention of pregnant women at risk to develop GD, and especially those with pregestational excess weight, since this status was found to be associated with detectable transgenerational brain changes. These effects may be due to the absence of specific and individualized intervention in these mothers during pregnancy. 2023-03-02T08:15:34Z 2023-03-02T08:15:34Z 2022-05-23 journal article Jordi Manuello... [et al.]. Influence of Gestational Diabetes and Pregestational Maternal BMI on the Brain of Six-Year-Old Offspring, Pediatric Neurology, Volume 133, 2022, Pages 55-62, ISSN 0887-8994, [https://doi.org/10.1016/j.pediatrneurol.2022.05.005] https://hdl.handle.net/10481/80330 10.1016/j.pediatrneurol.2022.05.005 eng info:eu-repo/grantAgreement/EC/H2020/633595 http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier