<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/79194">
      <dc:title>The Assessment of Skin Homeostasis Changes after Using Different Types of Excipients in Healthy Individuals</dc:title>
      <dc:creator>Ordóñez Toro, Abraham</dc:creator>
      <dc:creator>Montero Vílchez, Trinidad</dc:creator>
      <dc:creator>Muñoz Baeza, José</dc:creator>
      <dc:creator>Sanabria de la Torre, Raquel</dc:creator>
      <dc:creator>Buendía Eisman, Agustín</dc:creator>
      <dc:creator>Arias Santiago, Salvador Antonio</dc:creator>
      <dc:subject>Excipient</dc:subject>
      <dc:subject>Topical drugs</dc:subject>
      <dc:subject>Vaseline</dc:subject>
      <dc:subject>Petrolatum jelly</dc:subject>
      <dc:subject>W/O emulsion</dc:subject>
      <dc:subject>O/W emulsion</dc:subject>
      <dc:subject>Foam</dc:subject>
      <dc:subject>Beeler base</dc:subject>
      <dc:description>Excipients are used as vehicles for topical treatments; however, there are not many studies&#xd;
that evaluate the impact of different excipients themselves. The aim of this research is to assess skin&#xd;
homeostasis changes in healthy individuals after using water/oil (W/O), oil/water (O/W), Beeler&#xd;
base, foam and Vaseline excipients. A within-person randomized trial was conducted that included&#xd;
healthy individuals without previous skin diseases. Skin barrier function parameters, including&#xd;
stratum corneum hydration (SCH), transepidermal water loss (TEWL), pH, temperature, erythema,&#xd;
melanin and elasticity (R0, R2, R5 and R7), were measured on the volar forearm before and after&#xd;
using each excipient. Sixty participants were included in the study, with a mean age of 32 years.&#xd;
After applying w/o excipient erythema decreased by 25 AU, (p &lt; 0.001) and elasticity increased by&#xd;
6%. After using the o/w excipient, erythema decreased by 39.36 AU (p &lt; 0.001) and SCH increased&#xd;
by 6.85 AU (p = 0.009). When applying the Beeler excipient, erythema decreased by 41.23 AU&#xd;
(p &lt; 0.001) and SCH increased by 15.92 AU (p &lt; 0.001). Foam and Vaseline decreased TEWL and&#xd;
erythema. Excipients have a different impact on skin barrier function. Knowing the effect of excipients&#xd;
on the skin could help to develop new topical treatments and help specialists to choose the best&#xd;
excipient according to the pathology</dc:description>
      <dc:date>2023-01-20T12:11:06Z</dc:date>
      <dc:date>2023-01-20T12:11:06Z</dc:date>
      <dc:date>2022-12-12</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Ordoñez-Toro, A... [et al.]. The Assessment of Skin Homeostasis Changes after Using Different Types of Excipients in Healthy Individuals. Int. J. Environ. Res. Public Health 2022, 19, 16678. [https://doi.org/10.3390/ijerph192416678]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/79194</dc:identifier>
      <dc:identifier>10.3390/ijerph192416678</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>