<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/78417">
      <dc:title>Benefits of Participation in Clinical Trials: An Umbrella Review</dc:title>
      <dc:creator>Bouzalmate Hajjaj, Amira</dc:creator>
      <dc:creator>Massó Guijarro, Paloma</dc:creator>
      <dc:creator>Saeed Khan, Khalid</dc:creator>
      <dc:creator>Bueno Cavanillas, Aurora</dc:creator>
      <dc:creator>Cano Ibáñez, Naomi</dc:creator>
      <dc:subject>Participation</dc:subject>
      <dc:subject>Non-participants</dc:subject>
      <dc:subject>Systematic reviews</dc:subject>
      <dc:subject>Umbrella review</dc:subject>
      <dc:subject>Health changes</dc:subject>
      <dc:subject>Randomised controlled trial</dc:subject>
      <dc:description>Participation in randomised clinical trials (RCTs) entails taking part in the discovery of&#xd;
effects of health care interventions. The question of whether participants’ outcomes are different&#xd;
to those of non-participants remains controversial. This umbrella review was aimed at assessing&#xd;
whether there are health benefits of participation in RCTs, compared to non-participation. After&#xd;
prospective registration (PROSPERO CRD42021287812), we searched the Medline, Scopus,Web of&#xd;
Science and Cochrane Library databases from inception to June 2022 to identify relevant systematic&#xd;
reviews with or without meta-analyses. Data extraction and study quality assessment (AMSTAR-2)&#xd;
were performed by two independent reviewers. Of 914 records, six systematic reviews summarising&#xd;
380 comparisons of RCT participants with non-participants met the inclusion criteria. In two reviews,&#xd;
the majority of comparisons were in favour of participation in RCTs. Of the total of comparisons,&#xd;
69 (18.7%) were in favour of participation, reporting statistically significant better outcomes for&#xd;
patients treated within RCTs, 264 (71.7%) comparisons were not statistically significant, and 35 (9.5%)&#xd;
comparisons were in favour of non-participation. None of the reviews found a harmful effect of&#xd;
participation in RCTs. Our findings suggest that taking part in RCTs may be beneficial compared&#xd;
to non-participation.</dc:description>
      <dc:date>2022-12-13T10:08:28Z</dc:date>
      <dc:date>2022-12-13T10:08:28Z</dc:date>
      <dc:date>2022-11-21</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Bouzalmate-Hajjaj, A... [et al.]. Benefits of Participation in Clinical Trials: An Umbrella Review. Int. J. Environ. Res. Public Health 2022, 19, 15368. [https://doi.org/10.3390/ijerph192215368]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/78417</dc:identifier>
      <dc:identifier>10.3390/ijerph192215368</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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