Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study González Gil, Esther M. Anguita Ruiz, Augusto Gil Hernández, Ángel Gil Campos, Mercedes Aguilera García, Concepción María Puberty Metabolic syndrome Inflammation Cardiovascular risk Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during puberty. Seventy-five children from the PUBMEP study (33 females), aged 4–18 years, were included. Cardiovascular and inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein (CRP), leptin, tumor necrosis factor-alpha (TNFα), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed. Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and tPAI (p < 0.05)). For prepubertal children with obesity, the odds of developing MetS in puberty were significantly higher in those having high zBMI (OR = 4.27; CI: 1.39–22.59) or high concentrations of tPAI (OR = 1.19; CI: 1.06–1.43). Conclusion: Those with obesity with higher prepubertal tPAI plasma levels had 19% higher odds of having MetS at puberty highlighting the existence of association between MetS, obesity, and inflammation already in puberty. Thus, assessing cardiometabolic and inflammatory status in children with obesity already at prepuberty is key to avoiding future comorbidities. 2022-12-09T11:52:35Z 2022-12-09T11:52:35Z 2022-11-15 journal article González-Gil, E.M... [et al.]. Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study. Eur J Pediatr (2022). [https://doi.org/10.1007/s00431-022-04702-6] https://hdl.handle.net/10481/78361 10.1007/s00431-022-04702-6 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Springer