Associations between heart rate variability and maximal fat oxidation in two different cohorts of healthy sedentary adults González Acedo, Anabel Plaza Florido, Abel Adrián Amaro Gahete, Francisco José Alcántara Alcántara, Juan Manuel Parasympathetic Heart rate Endurance Fatmax Exercise Kubios Background and aims: Resting heart rate variability (HRV) and maximal fat oxidation (MFO) during exercise are both considered as a noninvasive biomarkers for early detection of car-diovascular risk factors. Thus, this study aimed to analyze the relationship between resting HRV parameters and MFO during exercise, and the intensity of exercise that elicit MFO (Fatmax) in healthy sedentary adults. Methods and results: A total of 103 healthy young adults (22.2 +/- 2.3 years old, 67% female; from the ACTIBATE cohort) and 67 healthy middle-aged adults (53.1 +/- 5.0 years old, 52% female; from the FIT-AGEING cohort) were included in this cross-sectional study. HRV was assessed using a Polar RS800CX heart rate monitor, while MFO and Fatmax were determined during a graded ex-ercise treadmill test using indirect calorimetry. No significant associations were observed for healthy young adults (standardized b coefficients ranged from-0.063 to 0.094, and all P >= 0.347) and for middle-aged adults (standardized b coefficients ranged from-0.234 to 0.090, and all P >= 0.056). Nevertheless, only a weak association was observed between one HRV parameter in time-domain (the percentage of R-R intervals that shows a difference higher than 50 ms [pNN50]) and MFO in the cohort of middle-aged adults (b coefficient =-0.279, and P = 0.033). Conclusion: The results of this study suggest that resting HRV parameters are not associated with MFO and Fatmax during exercise in two independent cohorts of healthy sedentary young and middle-aged adults, respectively. 2022-12-07T08:30:11Z 2022-12-07T08:30:11Z 2022-06-22 journal article Anabel González-Acedo... [et al.]. Associations between heart rate variability and maximal fat oxidation in two different cohorts of healthy sedentary adults, Nutrition, Metabolism and Cardiovascular Diseases, Volume 32, Issue 10, 2022, Pages 2338-2347, ISSN 0939-4753, [https://doi.org/10.1016/j.numecd.2022.06.015] https://hdl.handle.net/10481/78323 10.1016/j.numecd.2022.06.015 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Elsevier