<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/78185">
      <dc:title>The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches</dc:title>
      <dc:creator>Saeed, Marwa M.</dc:creator>
      <dc:creator>Fernández Ochoa, Álvaro</dc:creator>
      <dc:creator>Cádiz Gurrea, María de la Luz</dc:creator>
      <dc:creator>Segura Carretero, Antonio</dc:creator>
      <dc:subject>Cyperus esculentus</dc:subject>
      <dc:subject>Tiger nut</dc:subject>
      <dc:subject>Metabolomics</dc:subject>
      <dc:subject>UHPLC-ESI-QTOF-MS/MS</dc:subject>
      <dc:subject>Foodomics</dc:subject>
      <dc:subject>Scopolamine</dc:subject>
      <dc:subject>Memory impairments</dc:subject>
      <dc:description>The aim of the present study is to investigate the phytochemical composition of tiger&#xd;
nut (TN) (Cyperus esculentus L.) and its neuroprotective potential in scopolamine (Scop)-induced&#xd;
cognitive impairment in rats. The UHPLC-ESI-QTOF-MS analysis enabled the putative annotation of&#xd;
88 metabolites, such as saccharides, amino acids, organic acids, fatty acids, phenolic compounds and&#xd;
flavonoids. Treatment with TN extract restored Scop-induced learning and memory impairments. In&#xd;
parallel, TN extract succeeded in lowering amyloid beta,  -secretase protein expression and acetylcholine&#xd;
esterase (AChE) activity in the hippocampus of rats. TN extract decreased malondialdehyde&#xd;
levels, restored antioxidant levels and reduced proinflammatory cytokines as well as the Bax/Bcl2&#xd;
ratio. Histopathological analysis demonstrated marked neuroprotection in TN-treated groups. In&#xd;
conclusion, the present study reveals that TN extract attenuates Scop-induced memory impairments&#xd;
by diminishing amyloid beta aggregates, as well as its anti-inflammatory, antioxidant, anti-apoptotic&#xd;
and anti-AChE activities.</dc:description>
      <dc:date>2022-11-29T13:04:50Z</dc:date>
      <dc:date>2022-11-29T13:04:50Z</dc:date>
      <dc:date>2022-10-21</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Saeed, M.M... [et al.]. The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches. Molecules 2022, 27, 7118. [https://doi.org/10.3390/molecules27207118]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/78185</dc:identifier>
      <dc:identifier>10.3390/molecules27207118</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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