No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial Martínez Téllez, Borja Manuel Sánchez Delgado, Guillermo Acosta, Francisco M. Alcántara Alcántara, Juan Manuel Amaro Gahete, Francisco José Martínez Ávila, Wendy D. Merchán Ramírez, Elisa Muñoz Hernández, María Victoria Osuna Prieto, Francisco Javier Jurado Fasoli, Lucas Xu, Huiwen Ortiz Álvarez, Lourdes Arias Téllez, María José Méndez Gutiérrez, Andrea Ortega Porcel, Francisco Bartolomé Aguilera García, Concepción María Llamas Elvira, José Manuel Gil Hernández, Ángel Ruiz Ruiz, Jonatan Exercise modulates both brown adipose tissue (BAT)metabolismand white adipose tissue (WAT) browning in murine models. Whether this is true in humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance and resistance training, on BAT volume and activity (primary outcome). The study was carried out in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada (Spain). One hundred and forty-five young sedentary adults were assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse events were recorded. 97 participants (34 men, 63 women) were included in the final analysis (Control; n = 35, MOD-EX; n=31, and VIG-EX; n=31).We observed no changes in BAT volume (Δ Control: −22.2 ± 52.6ml; Δ MOD-EX: −15.5 ± 62.1ml, Δ VIG-EX: −6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose uptake (SUVpeak Δ Control: −2.6 ± 3.1ml; Δ MOD-EX: −1.2 ± 4.8, Δ VIG-EX: −2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did not find any evidence of an exercise-induced change on BAT volume or activity in young sedentary adults. 2022-10-03T07:46:39Z 2022-10-03T07:46:39Z 2022-09-12 journal article Martinez-Tellez, B... [et al.]. No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial. Nat Commun 13, 5259 (2022). [https://doi.org/10.1038/s41467-022-32502-x] https://hdl.handle.net/10481/77123 10.1038/s41467-022-32502-x eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Nature