<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/77013">
      <dc:title>The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review</dc:title>
      <dc:creator>Louro, Henriqueta</dc:creator>
      <dc:creator>Fernández Cabrera, Mariana Fátima</dc:creator>
      <dc:creator>Olea Serrano, Nicolás</dc:creator>
      <dc:subject>Polycyclic aromatic hydrocarbons</dc:subject>
      <dc:subject>Occupational exposure</dc:subject>
      <dc:subject>Human biomonitoring</dc:subject>
      <dc:subject>Exposure biomarker</dc:subject>
      <dc:subject>Effect biomarker</dc:subject>
      <dc:description>Polycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on&#xd;
workers’ health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has&#xd;
becomemore common in recent years, but the data generated need an overall viewtomake themmore usable&#xd;
by regulators and policymakers. This comprehensive review, developed under theHuman Biomonitoring&#xd;
for Europe (HBM4EU) Initiative,was based on the literature available from2008–2022, aiming to present and&#xd;
discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations&#xd;
of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most&#xd;
frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), ametabolite of pyrene. As&#xd;
effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and&#xd;
genotoxicity (blood DNA strand-breaks) are themost common. Overall, a need to advance newharmonized&#xd;
approaches both in data and sample collection and in the use of appropriate biomarkers in occupational&#xd;
studies to obtain reliable and comparable data on PAHexposure in different industrial sectors,was noted.&#xd;
Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk,&#xd;
thus enabling preventive riskmitigation andmanagementmeasures.</dc:description>
      <dc:date>2022-09-27T10:39:02Z</dc:date>
      <dc:date>2022-09-27T10:39:02Z</dc:date>
      <dc:date>2022-08-17</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Louro, H... [et al.]. The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review. Toxics 2022, 10, 480. [https://doi.org/10.3390/toxics10080480]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/77013</dc:identifier>
      <dc:identifier>10.3390/toxics10080480</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:relation>info:eu-repo/grantAgreement/EC/H2020/733032</dc:relation>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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