Genetic Polymorphisms in VEGFR Coding Genes (FLT1/KDR) on Ranibizumab Response in High Myopia and Choroidal Neovascularization Patients Blánquez Martínez, David Díaz Villamarín, Xando García Rodríguez, Sonia Antúnez Rodríguez, Alba Pozo Agundo, Ana Martínez González, Luis Javier Muñoz Ávila, José Ignacio Dávila Fajardo, Cristina Lucía Pharmacogenetics Myopia Ranibizumab Precision medicine VEGFR anti-VEGF FLT1 KDR A severe form of myopia defined as pathologic/high myopia is the main cause of visual impairment and one of the most frequent causes of blindness worldwide. It is characterized by at least 6 diopters or axial length (AL) of eyeball > 26 mm and choroidal neovascularization (CNV) in 5 to 10% of cases. Ranibizumab is a humanized recombinant monoclonal antibody fragment targeted against human vascular endothelial growth factor A (VEGF-A) used in the treatment of CNV. It acts by preventing VEGF-A from interacting with its receptors (VEGFR-1 and -2) encoded by the FLT1 and KDR genes. Several studies found that the KDR and FLT1 genotypes may represent predictive determinants of efficacy in ranibizumab-treated neovascular age-related macular degeneration (nAMD) patients. We performed a retrospective study to evaluate the association of single nucleotide polymorphisms (SNPs) in VEGFR coding genes with the response rate to ranibizumab in patients with high myopia and CNV. In the association study of genotypes in FLT1 with the response to ranibizumab, we found a significant association between two FLT1 variants (rs9582036, rs7993418) with ranibizumab efficacy at the 12-month follow-up. About the KDR gene, we found that two KDR variants (rs2305948, rs2071559) are associated with best-corrected visual acuity (BCVA) improvement and KDR (rs2239702) is associated with lower rates of BCVA worsening considering a 12-month follow-up period. 2022-09-27T07:55:35Z 2022-09-27T07:55:35Z 2022-07-26 journal article Blánquez-Martínez, D... [et al.]. Genetic Polymorphisms in VEGFR Coding Genes (FLT1/KDR) on Ranibizumab Response in High Myopia and Choroidal Neovascularization Patients. Pharmaceutics 2022, 14, 1555. [https://doi.org/10.3390/pharmaceutics14081555] https://hdl.handle.net/10481/77000 10.3390/pharmaceutics14081555 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI