<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/76688">
      <dc:title>Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort</dc:title>
      <dc:creator>Martínez Urbistondo, Diego</dc:creator>
      <dc:creator>Bueno Cavanillas, Aurora</dc:creator>
      <dc:subject>NAFLD</dc:subject>
      <dc:subject>Metabolic syndrome</dc:subject>
      <dc:subject>Mediterranean diet</dc:subject>
      <dc:subject>Physical activity</dc:subject>
      <dc:subject>HRQoL</dc:subject>
      <dc:description>Objective: To evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the&#xd;
impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic&#xd;
syndrome (MetS).&#xd;
Methods: Baseline and 1 year follow up data from the PREDIMED-plus cohort (men and&#xd;
women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to&#xd;
an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were&#xd;
assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to&#xd;
evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical&#xd;
analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as&#xd;
affected by lifestyle during 1 year of follow up.&#xd;
Results: Data from 5205 patients with mean age of 65 years and a 48% of female&#xd;
participants. Adjusted linear multivariate mixed regression models showed that patients&#xd;
with lower probability of NAFLD (HSI &lt; 36 points) were more responsive to er-MeDiet (b&#xd;
0.64 vs b 0.05 per er-MeDiet adherence point, p&lt; 0.01) and PA (b 0.05 vs b 0.01 per&#xd;
MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-&#xd;
36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/&#xd;
week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in&#xd;
patients with lower probability of NAFLD.&#xd;
Conclusion: The evaluation of NAFLD by the HSI index in patients with MetS might&#xd;
identify subjects with different prospective sensitivity to lifestyle changes in terms of&#xd;
physical HRQoL (http://www.isrctn.com/ISRCTN89898870).</dc:description>
      <dc:date>2022-09-14T11:10:28Z</dc:date>
      <dc:date>2022-09-14T11:10:28Z</dc:date>
      <dc:date>2022-06-29</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Martínez-Urbistondo D... [et al.] (2022) Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort. Front. Endocrinol. 13:868795. doi: [10.3389/fendo.2022.868795]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/76688</dc:identifier>
      <dc:identifier>10.3389/fendo.2022.868795</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:relation>info:eu-repo/grantAgreement/EC/FP7/340918</dc:relation>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>Frontiers</dc:publisher>
   </ow:Publication>
</rdf:RDF>