Singular Olive Oils from a Recently Discovered Spanish North-Western Cultivar: An Exhaustive 3-Year Study of Their Chemical Composition and In-Vitro Antidiabetic Potential Figueiredo González, María Olmo García, Lucía Serrano García, Irene Carrasco Pancorbo, Alegría Autochthonous cultivar Virgin olive oil Phenolic compounds Diabetes mellitus alpha-glucosidase inhibition Multivariant chemometric tools In this work, the quality and physicochemical parameters, phenolic composition, and antidiabetic potential of olive oils obtained from olives belonging to centenarian olive trees of the so-called 'Mansa de Figueiredo' cultivar were evaluated during three consecutive crop seasons (2017-2019). The oils produced during the three crop years were classified as extra virgin based on the quality-related indices, sensory analysis, and the genuineness-related parameters. In addition, LC-ESI-TOF MS was used to get a comprehensive characterisation of the phenolic fraction while LC-ESI-IT MS was applied for quantitation purposes. The content of phenolic compounds (ranging from 1837 to 2434 mg/kg) was significantly affected by the harvest year due to the environmental conditions and ripening index. Furthermore, although significant differences in the inhibitory effects against the alpha-glucosidase enzyme for the EVOOs extracted throughout the three successive years were detected, all the studied EVOOs exhibited a stronger inhibitor effect than that found for acarbose. 2022-09-12T07:31:11Z 2022-09-12T07:31:11Z 2022-06-23 journal article Figueiredo-González, M... [et al.]. Singular Olive Oils from a Recently Discovered Spanish North-Western Cultivar: An Exhaustive 3-Year Study of Their Chemical Composition and In-Vitro Antidiabetic Potential. Antioxidants 2022, 11, 1233. [https://doi.org/10.3390/antiox11071233] http://hdl.handle.net/10481/76618 10.3390/antiox11071233 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI