A chemical nano-reactor based on a levitated nanoparticle in vacuum Ricci, F. Rica Alarcón, Raúl Alberto A single levitated nanoparticle is used as a nano-reactor for studying surface chemistry at the nanoscale. Optical levitation under controlled pressure, surrounding gas composition, and humidity provides extreme control over the nanoparticle, including dynamics, charge, and surface chemistry. Using a single nanoparticle avoids ensemble averages and allows to study how the presence of silanol groups at its surface a ects the adsorption and desorption of water from the background gas with unprecedented real time, spatial, and temporal resolution. Here, we demonstrate the unique potential of this versatile platform by studying the Zhuravlev model in silica particles. In contrast to standard methods, our system allowed the rst observation of an abrupt and irreversible change in scattering cross section, mass, and mechanical eigenfrequency during the dehydroxylation process, indicating changes in density, refractive index and volume. 2022-07-27T11:01:36Z 2022-07-27T11:01:36Z 2022-02-24 journal article Published version: ACS Nano 2022, 16, 6, 8677–8683. [https://doi.org/10.1021/acsnano.2c01693] http://hdl.handle.net/10481/76381 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional American Chemical Society