Lidocaine Pharmaceutical Multicomponent Forms: A Story about the Role of Chloride Ions on Their Stability Verdugo Escamilla, Cristóbal Alarcón Payer, Carolina Acebedo Martínez, Francisco Javier Fernández Penas, Raquel Domínguez Martín, Alicia Choquesillo Lazarte, Duane Lidocaine Cocrystals Mechanochemistry Multicomponent materials API Pharmaceutical solids Solubility In this investigation, three new crystal forms of lidocaine, and another three of lidocaine hydrochloride with hydroquinone, resorcinol, and pyrogallol were synthetised. All the new forms were characterised using multiple techniques, PXRD, SC-XRD, DSC, and FTIR. The stability of the forms was studied, and, for the more stable forms, i.e., (lidhcl) forms, the solubility was determined through FTIR analysis. The new crystalline forms obtained with (lidhcl) and the three coformers showed an interesting steric stabilisation mechanism of the oxidation of hydroxybenzenes and showed good physicochemical properties with respect to (lidhcl), constituting a mechanism of modulation of the physicochemical properties. 2022-07-13T08:31:11Z 2022-07-13T08:31:11Z 2022-06-06 journal article Verdugo-Escamilla, C... [et al.]. Lidocaine Pharmaceutical Multicomponent Forms: A Story about the Role of Chloride Ions on Their Stability. Crystals 2022, 12, 798. [https://doi.org/10.3390/cryst12060798] http://hdl.handle.net/10481/75978 10.3390/cryst12060798 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI