A Systematic Review and Meta-Analysis of Systemic Antibiotic Therapy in the Treatment of Peri-Implantitis Toledano Osorio, Manuel Vallecillo, Cristina Toledano, Raquel Sánchez Aguilera, Fátima Toledano Osorio, María Muñoz Soto, Esther Vallecillo Rivas, Marta Antibiotics Bleeding on probing Peri-implantitis Probing pocket depth Antibiotic resistance Antibacterial agents Research has been conducted into the advantages of the systemic administration of antibiotics. The aim of this systematic review and meta-analysis was to assess the efficacy of systemic antibiotic administration in the treatment of peri-implantitis in terms of bleeding on probing (BoP) and probing pocket depth (PPD). Literature searches were performed across PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) to identify randomized controlled trials and observational clinical studies. After peri-implantitis treatment, PPD was reduced by 0.1 mm (p = 0.58; IC 95% [-0.24, 0.47]), indicating a non-significant effect of antibiotic administration on PPD. The BoP odds ratio value was 1.15 (p = 0.5; IC 95% [0.75, 1.75]), indicating that the likelihood of bleeding is almost similar between the test and control groups. Secondary outcomes were found, such as reduced clinical attachment level, lower suppuration and recession, less bone loss, and a reduction in total bacterial counts. In the treatment of peri-implantitis, the systemic antibiotic application reduces neither PPD nor BoP. Therefore, the systemic administration of antibiotics, in the case of peri-implantitis, should be rethought in light of the present results, contributing to address the problem of increasing antibiotic resistance. 2022-06-30T09:53:49Z 2022-06-30T09:53:49Z 2022-05-26 journal article Toledano-Osorio, M... [et al.]. A Systematic Review and Meta-Analysis of Systemic Antibiotic Therapy in the Treatment of Peri-Implantitis. Int. J. Environ. Res. Public Health 2022, 19, 6502. [https://doi.org/10.3390/ijerph19116502] http://hdl.handle.net/10481/75740 10.3390/ijerph19116502 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI