<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/75715">
      <dc:title>Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes</dc:title>
      <dc:creator>Sánchez Martín, Victoria</dc:creator>
      <dc:creator>Plaza Calonge, María del Carmen</dc:creator>
      <dc:creator>Soriano Lerma, Ana del Carmen</dc:creator>
      <dc:creator>Ortiz González, Matilde</dc:creator>
      <dc:creator>Linde Rodríguez, Ángel</dc:creator>
      <dc:creator>Pérez Carrasco, Virginia</dc:creator>
      <dc:creator>Ramírez Macías, Inmaculada</dc:creator>
      <dc:creator>Cuadros Celorrio, Marta Eugenia</dc:creator>
      <dc:creator>Gutiérrez Fernández, José</dc:creator>
      <dc:creator>Murciano Calles, Javier</dc:creator>
      <dc:creator>Rodríguez Manzaneque, Juan Carlos</dc:creator>
      <dc:creator>Soriano, Miguel</dc:creator>
      <dc:creator>García Salcedo, José Antonio</dc:creator>
      <dc:subject>G-quadruplex</dc:subject>
      <dc:subject>Phenol</dc:subject>
      <dc:subject>Gallic acid</dc:subject>
      <dc:subject>Cancer</dc:subject>
      <dc:subject>Colorectal cancer</dc:subject>
      <dc:description>Natural phenolic compounds have gained momentum for the prevention and treatment&#xd;
of cancer, but their antitumoral mechanism of action is not yet well understood. In the present&#xd;
study, we screened the antitumoral potential of several phenolic compounds in a cellular model of&#xd;
colorectal cancer (CRC).We selected gallic acid (GA) as a candidate in terms of potency and selectivity&#xd;
and extensively evaluated its biological activity. We report on the role of GA as a ligand of DNA&#xd;
G-quadruplexes (G4s), explaining several of its antitumoral effects, including the transcriptional&#xd;
inhibition of ribosomal and CMYC genes. In addition, GA shared with other established G4 ligands&#xd;
some effects such as cell cycle arrest, nucleolar stress, and induction of DNA damage. We further&#xd;
confirmed the antitumoral and G4-stabilizing properties of GA using a xenograft model of CRC.&#xd;
Finally, we succinctly demonstrate that GA could be explored as a therapeutic agent in a patient&#xd;
cohort with CRC. Our work reveals that GA, a natural bioactive compound present in the diet, affects&#xd;
gene expression by interaction with G4s both in vitro and in vivo and paves the way towards G4s&#xd;
targeting with phenolic compounds.</dc:description>
      <dc:date>2022-06-29T10:27:17Z</dc:date>
      <dc:date>2022-06-29T10:27:17Z</dc:date>
      <dc:date>2022-05-26</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Sanchez-Martin, V... [et al.]. Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes. Cancers 2022, 14, 2648. [https://doi.org/10.3390/cancers14112648]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/75715</dc:identifier>
      <dc:identifier>10.3390/cancers14112648</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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