<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/75671">
      <dc:title>Swine as the Animal Model for Testing New Formulations of Anti-Inflammatory Drugs: Carprofen Pharmacokinetics and Bioavailability of the Intramuscular Route</dc:title>
      <dc:creator>Gómez Segura, Lidia</dc:creator>
      <dc:creator>Soriano Ruiz, José Luis</dc:creator>
      <dc:subject>Population pharmacokinetics</dc:subject>
      <dc:subject>Tissue distribution</dc:subject>
      <dc:subject>Swine animal model</dc:subject>
      <dc:subject>Mass spectrometry</dc:subject>
      <dc:subject>Bioanalysis</dc:subject>
      <dc:subject>Carprofen</dc:subject>
      <dc:subject>Anti-inflammatory drugs</dc:subject>
      <dc:description>Carprofen (CP) is a non-steroidal anti-inflammatory drug (NSAID) frequently used to&#xd;
treat respiratory diseases in numerous small animals, but also in large species. CP is a formidable&#xd;
candidate for further therapeutic research of human inflammatory diseases using the pig as an animal&#xd;
model. However, CP administration in swine is very uncommon and respective pharmacokinetics/&#xd;
bioavailability studies are scarce. A simultaneous population pharmacokinetic analysis after CP&#xd;
intravenous and intramuscular administrations in pigs has shown high extent and rate of absorption&#xd;
and a similar distribution profile with respect to man and other mammals. However, clearance and&#xd;
half-life values found in swine suggest a slower elimination process than that observed in man and&#xd;
some other animal species. Although not reported in other species, liver and kidney concentrations&#xd;
achieved at 48 h post-intramuscular administration in pigs were ten times lower than those found in&#xd;
plasma. Simulations pointed to 4 mg/kg every 24 h as the best dosage regimen to achieve similar&#xd;
therapeutic levels to those observed in other animal species. All these findings support the use of pig&#xd;
as an animal model to study the anti-inflammatory effects of CP in humans.</dc:description>
      <dc:date>2022-06-27T08:27:51Z</dc:date>
      <dc:date>2022-06-27T08:27:51Z</dc:date>
      <dc:date>2022-05-12</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Gómez-Segura, L... [et al.]. Swine as the Animal Model for Testing New Formulations of Anti-Inflammatory Drugs: Carprofen Pharmacokinetics and Bioavailability of the Intramuscular Route. Pharmaceutics 2022, 14, 1045. [https://doi.org/10.3390/pharmaceutics14051045]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/75671</dc:identifier>
      <dc:identifier>10.3390/pharmaceutics14051045</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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