Managing the Systemic Impact of Periodontitis Mainas, Giuseppe Magán Fernández, Antonio Mesa Aguado, Francisco Luis Periodontitis Inflammation Biomarkers Quality of life Public health Cardiovascular diseases Pregnancy outcome Diabetes mellitus Metabolic syndrome Psoriasis Periodontitis is a microbially driven host-mediated disease that leads to loss of periodontal attachment and bone. It is associated with elevation of systemic inflammatory markers and with the presence of systemic co-morbidities. Furthermore, periodontal treatment leads to a 24–48 h-long acute local and systemic inflammatory response. This systemic response might increase the burden of patients with compromised medical history and/or uncontrolled systemic diseases. The correlation between periodontitis and systemic diseases, the impact of periodontitis on the quality of life and public health, the effects of periodontal treatment on systemic health and disease, and the available methods to manage systemic inflammation after periodontal therapy are discussed. The main focus then shifts to a description of the existing evidence regarding the impact of periodontitis and periodontal treatment on systemic health and to the identification of approaches aiming to reduce the effect of periodontitis on systemic inflammation. 2022-06-15T06:59:33Z 2022-06-15T06:59:33Z 2022-04-29 journal article Mainas, G... [et al.]. Managing the Systemic Impact of Periodontitis. Medicina 2022, 58, 621. [https://doi.org/10.3390/medicina58050621] http://hdl.handle.net/10481/75492 10.3390/medicina58050621 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI