Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial Vázquez Lorente, Héctor Molina López, Jorge Herrera Quintana, Lourdes María Gamarra Morales, Yenifer Quintero Osso, Bartolomé López González, Beatriz Planells Del Pozo, Elena María Postmenopausal women Antioxidant status Zinc Supplementation Total antioxidant capacity This research received external funding by Zinc-Net-The Network for the Biology of Zinc (FA COST Action TD1304) and FIS Project from Carlos III Health Institute [REF.PI10/1993]. The previous projects had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. H´ector V´azquez-Lorente and Lourdes Herrera-Quintana are under a FPU fellowship from the Spanish Ministry of Education. Background & aims: Menopausal hormonal changes increase the risk of deficiencies of minerals such as zinc (Zn), which could further worsen the decreased antioxidant defense of postmenopausal women. This study assesses the effect of 8 weeks of Zn supplementation upon the antioxidant status and clinical nutritional parameters of a postmenopausal population. Methods: Fifty-one postmenopausal women were divided into two groups: placebo (PbG) and zinc supplementation (ZnG). Mineral status was determined by Flame Atomic Absorption Spectrophotometry (FAAS). Total Antioxidant Capacity (TAC) and Superoxide Dismutase (SOD) were analyzed by kinetic colorimetric methods. Glutathione Peroxidase (GPx) was assessed by an enzymatic immunological method. Results: Poor Zn status was initially observed in erythrocyte samples. Total antioxidant capacity showed a significant correlation (r = 0.730; p < 0.05) to erythrocyte Zn after the intervention (ZnG: r = 0.96; p < 0.001). Moreover, erythrocyte Zn concentration in ZnG was positively correlated to GPx activity after the intervention (r = 0.61; p < 0.01). Conclusions: The postmenopausal women initially presented Zn deficiency, and the status of this mineral improved after the intervention. Zinc supplementation may be an effective approach for correcting the observed deficiencies, enhancing antioxidant defense in this risk population. 2022-06-07T06:48:55Z 2022-06-07T06:48:55Z 2022-03-09 journal article Héctor Vázquez-Lorente... [et al.]. Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial, Experimental Gerontology, Volume 162, 2022, 111766, ISSN 0531-5565, [https://doi.org/10.1016/j.exger.2022.111766] http://hdl.handle.net/10481/75291 10.1016/j.exger.2022.111766 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España Elsevier