Acute Effect of a Dietary Multi-Ingredient Nootropic as a Cognitive Enhancer in Young Healthy Adults: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial Medrano, María Molina Hidalgo, Cristina Alcántara Alcántara, Juan Manuel Ruiz Ruiz, Jonatan Jurado Fasoli, Lucas This study was funded by the Harrison Sport Nutrition. The company played no role in the study design, methodology, analysis, and interpretation of the results. This study was also supported by the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), and University of Granada Plan Propio de Investigación 2021–Excellence actions: Unit of Excellence on Exercise and Health (UCEES). LJ-F was supported by the Spanish Ministry of Education (FPU19/01609). MM was supported by the Fondo Social Europeo and Sistema Nacional de Garantía Juvenil (Ref. 8025). JA was supported by the University of Granada Plan Propio de Investigación 2020 Programa de Contratos Puente. Aim: To study the acute effect of a dietary multi-ingredient nootropic on cognitive performance in young healthy adults. We also analyzed the influence of the dietary multi-ingredient nootropic on emotional state, heart rate (HR), and heart rate variability (HRV). Methods: This is a randomized, triple-blinded, placebo-controlled, crossover trial. In total, 26 young healthy adults (50% women; 24.9 ± 3.3 years old) ingested 10 g of a dietary multi-ingredient nootropic [Evo-Gamers; Harrison Sport Nutrition (HSN), Granada, Spain] or placebo (maltodextrin) in a randomized order (clinicaltrials.gov No. NCT04790188). After 30 min of the ingestion, participants performed a battery of cognitive performance tests to measure the processing speed, inhibitory control, working memory, cognitive flexibility, creativity, and verbal fluency. The emotional status was assessed through questionnaires, and HR and HRV were measured using a heart rate monitor. Results: In comparison with placebo, the acute ingestion of the nootropic showed a significantly better response time in several cognitive tests (i.e., processing speed, inhibitory control, spatial working memory, and cognitive flexibility, all P < 0.05 and effect size range of 0.4-0.6). It also displayed a higher accuracy in the processing speed, the inhibitory control, and cognitive flexibility tests (all P < 0.05; effect size ranged from 0.4 to 0.6). Furthermore, the nootropic showed a higher creativity and positive emotions and lower sadness-depression emotions, whereas HR and HRV remained similar between placebo vs. nootropic conditions. However, there were no differences between the nootropic and placebo in verbal fluency, motivation, or anxiety (all P > 0.05). Conclusion: An acute ingestion of a dietary multi-ingredient nootropic enhances cognitive performance in comparison with placebo without negatively influencing HR or HRV in young healthy adults. 2022-06-03T06:55:19Z 2022-06-03T06:55:19Z 2022-05-12 info:eu-repo/semantics/article Medrano M... [et al.] (2022) Acute Effect of a Dietary Multi-Ingredient Nootropic as a Cognitive Enhancer in Young Healthy Adults: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial. Front. Nutr. 9:858910. doi: [10.3389/fnut.2022.858910] http://hdl.handle.net/10481/75221 10.3389/fnut.2022.858910 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Frontiers