A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet González Domenech, Pablo José Díaz Atienza, Francisco Gutiérrez Rojas, Luis Fernández Soto, María Luisa Diet Gluten Casein Autism spectrum disorders This research received funding from CTS549 group of Psiquiatry and Neurosciences from the University of Granada. Objective: Autism spectrum disorders (ASDs) appear in the early stages of neurodevelopment, and they remain constant throughout life. Currently, due to limitations in ASDs treatment, alternative approaches, such as nutritional interventions, have frequently been implemented. The aim of this narrative review is to gather the most relevant and updated studies about dietary interventions related to ASDs etiopathogenesis. Results: Our literature search focused on the gluten- and casein-free (GFCF) diet. The literature found shows the inexistence of enough scientific evidence to support a general recommendation of dietary intervention in children with ASD. Protocols and procedures for assessing risk and safety are also needed. Future lines: Prospective and controlled research studies with larger sample sizes and longer follow-up times are scarce and needed. In addition, studies considering an assessment of intestinal permeability, bacterial population, enzymatic, and inflammatory gastrointestinal activity are interesting to identify possible responders. Besides brain imaging techniques, genetic tests can also contribute as markers to evaluate the comorbidity of gastrointestinal symptoms. 2022-06-02T06:42:37Z 2022-06-02T06:42:37Z 2022-04-25 info:eu-repo/semantics/article González-Domenech, P.J... [et al.]. A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet. Nutrients 2022, 14, 1797. [https://doi.org/10.3390/nu14091797] http://hdl.handle.net/10481/75187 10.3390/nu14091797 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI