<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/74848">
      <dc:title>Calcifediol During Pregnancy Improves Maternal and Fetal Availability of Vitamin D Compared to Vitamin D3 in Rats and Modifies Fetal Metabolism</dc:title>
      <dc:creator>Gázquez, Antonio</dc:creator>
      <dc:creator>Barranco Pérez, Alejandro</dc:creator>
      <dc:creator>Rueda, Ricardo</dc:creator>
      <dc:subject>Availability</dc:subject>
      <dc:subject>Calcidiol</dc:subject>
      <dc:subject>Calcfediol</dc:subject>
      <dc:subject>Pregnancy</dc:subject>
      <dc:subject>Vitamin D</dc:subject>
      <dc:description>This research was funded by the Abbott Nutrition S.L. The funder&#xd;
was not involved in the study design, collection, analysis, and&#xd;
interpretation of data.</dc:description>
      <dc:description>The fetus depends on the transplacental transfer of vitamin D. Calcifediol (25-OH-D3) is&#xd;
the vitamin D metabolite that crosses the placenta. Previously, oral 25-OH-D3 improved&#xd;
serum 25-OH-D3 compared to vitamin D3 in non-pregnant subjects, although no&#xd;
studies are available in pregnant women. We evaluated the availability of oral 25-OH-D3&#xd;
compared to vitamin D3 during pregnancy, as well as, their levels in the fetus and effect&#xd;
on metabolism-related proteins. Twenty female rats per group were fed with 25 mg/kg&#xd;
of diet of vitamin D3 (1,000 UI vitamin D/kg diet) or with 25 mg/kg diet of 25-OH-D3.&#xd;
We analyzed 25-OH-D3 levels in maternal and fetal plasma; protein levels of vitamin&#xd;
D receptor (VDR), fatty acid translocase (FAT), and scavenger-receptor class B type-1&#xd;
(SR-B1) in both maternal liver and placenta; and protein levels of VDR and Glutamate&#xd;
decarboxylase (GAD67) in fetal brain. 25-OH-D3 doubled the concentration of 25-OHD3&#xd;
in both maternal and fetal plasma compared to vitamin D3. In addition, maternal liver&#xd;
VDR, FAT, and SR-BI increased significantly in the 25-OH-D3 group, but no changes&#xd;
were found in the placenta. Interestingly, 25-OH-D3 decreased GAD67 expression in&#xd;
the fetal brain and it also tended to decrease VDR (P = 0.086). In conclusion, 25-OHD3&#xd;
provided better vitamin D availability for both mother and fetus when administered&#xd;
during pregnancy compared to vitamin D3. No adverse effects on pregnancy outcomes&#xd;
were observed. The effects of 25-OH-D3 on the expression of VDR and GAD67 in fetal&#xd;
brain require further investigation.</dc:description>
      <dc:date>2022-05-16T11:40:02Z</dc:date>
      <dc:date>2022-05-16T11:40:02Z</dc:date>
      <dc:date>2022-04-12</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Gázquez A... [et al.] (2022) Calcifediol During Pregnancy Improves Maternal and Fetal Availability of Vitamin D Compared to Vitamin D3 in Rats and Modifies Fetal Metabolism. Front. Nutr. 9:871632. doi: [10.3389/fnut.2022.871632]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/74848</dc:identifier>
      <dc:identifier>10.3389/fnut.2022.871632</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>Frontiers</dc:publisher>
   </ow:Publication>
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