<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
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      <dc:title>Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review</dc:title>
      <dc:creator>Martínez Montoro, José Ignacio</dc:creator>
      <dc:creator>García Fontana, Beatriz</dc:creator>
      <dc:creator>García Fontana, Cristina</dc:creator>
      <dc:creator>Muñoz Torres, Manuel Eduardo</dc:creator>
      <dc:subject>Type 2 diabetes mellitus</dc:subject>
      <dc:subject>Bone fragility</dc:subject>
      <dc:subject>Fracture risk</dc:subject>
      <dc:subject>Bone structure</dc:subject>
      <dc:subject>Bone quality</dc:subject>
      <dc:description>This research was funded by Instituto de Salud Carlos III grants (PI18-00803, PI21-01069, and PI18-01235), co-funded by the European Regional Development Fund (FEDER) and by a Junta de Andalucia grant (PI-0268-2019). In addition, C.G-F. was funded by a postdoctoral fellowship from the Instituto de Salud Carlos III (CD20/00022).</dc:description>
      <dc:description>Bone fragility is a common complication in subjects with type 2 diabetes mellitus (T2DM).&#xd;
However, traditional techniques for the evaluation of bone fragility, such as dual-energy X-ray absorptiometry&#xd;
(DXA), do not perform well in this population. Moreover, the Fracture Risk Assessment&#xd;
Tool (FRAX) usually underestimates fracture risk in T2DM. Importantly, novel technologies for the&#xd;
assessment of one microarchitecture in patients with T2DM, such as the trabecular bone score (TBS),&#xd;
high-resolution peripheral quantitative computed tomography (HR-pQCT), and microindentation,&#xd;
are emerging. Furthermore, different serum and urine bone biomarkers may also be useful for&#xd;
the evaluation of bone quality in T2DM. Hence, in this article, we summarize the limitations of&#xd;
conventional tools for the evaluation of bone fragility and review the current evidence on novel&#xd;
approaches for the assessment of quality and bone microstructure alterations in patients with T2DM.</dc:description>
      <dc:date>2022-05-10T07:58:12Z</dc:date>
      <dc:date>2022-05-10T07:58:12Z</dc:date>
      <dc:date>2022-04-14</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Martínez-Montoro, J.I... [et al.]. Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review. J. Clin. Med. 2022, 11, 2206. [https://doi.org/10.3390/jcm11082206]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/74771</dc:identifier>
      <dc:identifier>10.3390/jcm11082206</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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