Parental insulin resistance is associated with unhealthy lifestyle behaviours independently of body mass index in children: The Feel4Diabetes study Giménez Legarre, Natalia González Gil, Esther M. Insulin resistance Lifestyle Family behaviours Children European The Feel4Diabetes-study adhered to the Declaration of Helsinki and the conventions of the Council of Europe on human rights and biomedicine and was approved by each local ethical committee. More specifically, in Belgium, by the Medical Ethics Committee of the Ghent University Hospital (ethical approval code: B670201524237; date approval: 21/04/15); in Bulgaria, by the Ethics Committee of the Medical University of Varna (ethical approval code: 52/10–3-201r; date approval: 10/03/16) and the Municipalities of Sofia and Varna, as well as the Ministry of Education and Science local representatives; in Finland, by the hospital district of Southwest Finland ethical committee (ethical approval code: 174/1801/2015; date approval: 13/03/15); in Greece, by the Bioethics Committee of Harokopio University (ethical approval code: 46/3–4-2015; date approval: 03/04/15) and the Greek Ministry of Education; in Hungary, by the National Committee for Scientific Research in Medicine (ethical approval code: 20095/2016/EKU; date approval: 29/03/16); and in Spain, by the Clinical Research Ethics Committee and the Department of Consumers’ Health of the Government of Aragón (ethical approval code: CP03/2016; date approval: 08/04/15). The authors would like to thank all families who participated and the members of the Feel4Diabetes-study Group (). We gratefully acknowledge the financial support of the European Community. The authors would like to thank all families who participated and the members of the Feel4Diabetes-study Group (). We gratefully acknowledge the financial support of the European Community. Parental health is associated with children’s health and lifestyles. Thus, the aim of the present study was to assess lifestyle behaviours of children of parents with insulin resistance (IR) and at risk of type 2 diabetes. 2117 European families from the Feel4Diabetes-study were identifed as being at risk for diabetes with the FINDRISC questionnaire and included in the present study. One parent and one child per family were included. Parental IR was considered when homeostasis model assessment (HOMA) was equal or higher than 2.5. Children’s screen-time, physical activity and diet were assessed and clustered by K-means. Weight and height were measured and children’s body mass index (BMI) was calculated. For children, a Healthy Diet Score (HDS) was calculated. Linear regression and multilevel logistic regression analyses were performed to assess the associations between parental IR and children’s lifestyle behaviours in 2021. Children of parents with IR had higher BMI (p<0.001) and spent more screen time (p=0.014) than those of non-IR parents. Children of parents with IR had a lower value in the breakfast and vegetable components of the HDS (p=0.008 and p=0.05). Four lifestyle clusters were found. Children of IR parents had higher odds of being in a non-healthy cluster (OR: 1.19; 95%CI: 1.001–1.437). Conclusion: Having an IR parent was associated with a high screen time and an increased probability of having an unhealthy lifestyle pattern in children. These data point out that children’s lifestyles should be assessed in families with IR parents to provide tailored interventions. 2022-04-22T07:57:50Z 2022-04-22T07:57:50Z 2022-03-26 info:eu-repo/semantics/article González-Gil, E.M., Giménez-Legarre, N., Cardon, G. et al. Parental insulin resistance is associated with unhealthy lifestyle behaviours independently of body mass index in children: The Feel4Diabetes study. Eur J Pediatr (2022). [https://doi.org/10.1007/s00431-022-04449-0] http://hdl.handle.net/10481/74451 10.1007/s00431-022-04449-0 eng info:eu-repo/grantAgreement/EC/H2020/643708 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Springer Science and Business Media Deutschland GmbH