Standardized Clinical Profiling in Spanish Patients with Chronic Tinnitus Haro Hernández, Elisheba Pérez Carpena, Patricia López Escámez, José Antonio Tinnitus K-clustering Machine learning ESIT screening questionnaire J.A.L.-E. and V.U. have received funds from H2020 Research and Innovation Program, Grant Agreement Number 848261 (UNITI). J.A.L.-E. has also received funds from the Andalusian Health Government (Grant PI-0027-2020). P.P.-C. has received funds from the Andalusian Health Government (Grant RH-0150-2020). Background: Tinnitus is a heterogeneous condition. The aim of this study as to compare the online and hospital responses to the Spanish version of European School for Interdisciplinary Tinnitus Research screening-questionnaire (ESIT-SQ) in tinnitus individuals by an unsupervised age clustering. Methods: A cross-sectional study was performed including 434 white Spanish patients with chronic tinnitus to assess the demographic and clinical profile through the ESIT-SQ, with 204 outpatients and 230 individuals from an online survey; a K-means clustering algorithm was used to classify both responses according to age. Results: Online survey showed a high proportion of Meniere’s disease (MD) patients compared to both the general population and the outpatient cohort. The responses showed statistically significant differences between groups regarding education level, tinnitus-related hearing disorders (MD, hyperacusis), sleep difficulties, dyslipidemia, and other tinnitus characteristics, including duration, type of onset, the report of mitigating factors and the use of treatments. However, these differences were partially confirmed after adjusting for age. Conclusions: Self-reported tinnitus surveys are a low confidence source for tinnitus phenotyping. Additional clinical evaluation is needed for tinnitus research to reach the diagnosis. Age-based cluster analysis might help to better define clinical profiles and to compare responses in ESIT-SQ among subgroups of patients with tinnitus. 2022-04-05T10:19:32Z 2022-04-05T10:19:32Z 2022-02-13 journal article Haro-Hernandez, E... [et al.]. Standardized Clinical Profiling in Spanish Patients with Chronic Tinnitus. J. Clin. Med. 2022, 11, 978. [https://doi.org/10.3390/jcm11040978] http://hdl.handle.net/10481/74132 10.3390/jcm11040978 eng info:eu-repo/grantAgreement/EC/H2020/848261 http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI