Maxillary sinus floor augmentation comparing bovine versus porcine bone xenografts mixed with autogenous bone graft. A split-mouth randomized controlled trial Galindo Moreno, Pablo Antonio Abril García, Darío Carrillo Gálvez, Ana Belén Zurita Martínez, Federico Martín Morales, Natividad O'Valle Ravassa, Francisco Javier Padial Molina, Miguel Anorganic bovine bone Bone biomaterial Implant dentistry Maxillary sinus augmentation Porcine bone mineral This investigation was conducted under an Investigator--Initiated Study partially funded by Dentsply Sirona Implants (Molndal, Sweden) through a research transfer agreement with the Technology Transfer Office of the University of Granada (number I--BI--17--026) and the Research Cathedra "Dentsply Sirona-UGR" agreed between Dentsply Sirona Iberia S.A.U. and the University of Granada. The authors are also supported by funding from Research Groups #CTS-138 and #CTS--1028 (Junta de Andalucia, Spain) The authors are grateful to Justin G. Davis for assistance with the English translation and to Emilio Couso-Queiruga for assistance with the volumetric radiographic analyses. Aim: To compare the effectiveness of two xenografts for maxillary sinus floor augmentation in terms of clinical, radiographical, histologic, and molecular outcomes. Materials and methods: A split-mouth randomized clinical trial was conducted at the University of Granada. Ten consecutive patients in need of bilateral two-staged maxillary sinus floor augmentation were included. Each patient received both biomaterials (porcine bone mineral and anorganic bovine bone), which were randomly assigned for bilateral sinus augmentation. The maxillary autogenous bone scraped from the sinus access window was mixed with each xenograft at a 20:80 ratio. After a healing period of 6 months, bone biopsies were collected with a trephine during the implant placement in the regenerated area. Histologic, histomorphometrical, immunohistochemical, and molecular outcomes were analyzed. Clinical and radiographical data throughout the treatment phases were also evaluated. Results: The resulting anatomic features were similar between both groups. After six months of graft consolidation, the graft resorption rates were similar between both biomaterials. The histologic, histomorphometrical, and immunohistochemical results showed no statistical differences between groups. Conclusion: Anorganic bovine bone and porcine bone mineral combined with maxillary autogenous cortical bone show similar biologic and radiologic features in terms of biomaterial resorption, osteoconduction, and osteogenesis when used for maxillary sinus floor augmentation. 2022-03-30T06:33:53Z 2022-03-30T06:33:53Z 2022-02-27 journal article Galindo-Moreno, P... [et al.] (2022). Maxillary sinus floor augmentation comparing bovine versus porcine bone xenografts mixed with autogenous bone graft. A split-mouth randomized controlled trial. Clinical Oral Implants Research, 00, 1– 13. [https://doi.org/10.1111/clr.13912] http://hdl.handle.net/10481/73923 10.1111/clr.13912 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España John Wiley & Sons