Cosmeceutical Potential of Major Tropical and Subtropical Fruit By-Products for a Sustainable Revalorization García Villegas, Abigail Rojas García, Alejandro Villegas Aguilar, María del Carmen Fernández Moreno, Patricia Cádiz Gurrea, María de la Luz Arráez Román, David Segura Carretero, Antonio Tropical fruits By-products Phenolic compounds Green extraction Cosmeceuticals Skin health The work was supported by the project P18-TP-3589 (Regional Ministry of Economy, Knowledge, Enterprise and Universities of Andalusia). The author A.R.-G. would like to thank the project P18-TP-3589, University of Granada and AGR274 group for the contract (265).The author A.G.-V. would like to thank the Spanish National Youth Guarantee Implementation Plan for her contract. The author M.d.C.V.-A. would like to thank the Spanish Ministry of Science,Innovation, and Universities for the grant FPU19/01146. The author M.d.l.L.C.-G. would like to thank the Regional Ministry of Economy, Knowledge, Enterprise and Universities of Andalusia for the contract for Young Researchers (PAIDI) at the University of Granada. The increasing production of tropical fruits followed by their processing results in tons of waste, such as skins or seeds. However, these by-products have been reported to be rich in bioactive compounds (BACs) with excellent properties of interest in the cosmeceutical industry: antioxidant, anti-aging, anti-inflammatory, antimicrobial and photoprotective properties. This review summarizes the tropical fruits most produced worldwide, their bioactive composition and the most important and studied therapeutic properties that their by-products can contribute to skin health, as well as the different approaches for obtaining these compounds using techniques by conventional (Soxhlet, liquid-liquid extraction or maceration) and non-conventional extractions (supercritical fluid extraction (SFE), ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), pressurized liquid extraction (PLE) and two-phase aqueous system), followed by their identification by HPLC-MS or GC-MS analysis. Moreover, this work encompasses several studies that may prove the effects of seeds and skins from tropical fruits against oxidative stress, hyperpigmentation, acne, aging or UV radiation. Therefore, the investigation of functional components present in tropical fruit by-products under a circular bioeconomy model could be of great interest for the cosmeceutical industry and a very promising option for obtaining new cosmeceutical formulations. 2022-03-25T08:20:23Z 2022-03-25T08:20:23Z 2022-01-21 journal article García-Villegas, A... [et al.]. Cosmeceutical Potential of Major Tropical and Subtropical Fruit By-Products for a Sustainable Revalorization. Antioxidants 2022, 11, 203. [https://doi.org/10.3390/antiox11020203] http://hdl.handle.net/10481/73740 10.3390/antiox11020203 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI