Recent Analytical Approaches for the Study of Bioavailability and Metabolism of Bioactive Phenolic Compounds Fernández Ochoa, Álvaro Cádiz Gurrea, María de la Luz Fernández Moreno, Patricia Rojas García, Alejandro Arráez Román, David Segura Carretero, Antonio Analytical chemistry Bioactive compounds Bioavailability Metabolism Phytochemicals Phenolic compounds Metabolomics Chromatography Mass spectrometry Untargeted This work was funded by the Ministry of Science, Innovation and Universities (grant number RTI2018-096724-B-C22), and the Regional Government of Andalusia (grant number A-AGR-226-UGR20). The study of the bioavailability of bioactive compounds is a fundamental step for the development of applications based on them, such as nutraceuticals, functional foods or cosmeceuticals. It is well-known that these compounds can undergo metabolic reactions before reaching therapeutic targets, which may also affect their bioactivity and possible applications. All recent studies that have focused on bioavailability and metabolism of phenolic and terpenoid compounds have been developed because of the advances in analytical chemistry and metabolomics approaches. The purpose of this review is to show the role of analytical chemistry and metabolomics in this field of knowledge. In this context, the different steps of the analytical chemistry workflow (design study, sample treatment, analytical techniques and data processing) applied in bioavailability and metabolism in vivo studies are detailed, as well as the most relevant results obtained from them. 2022-03-23T08:18:47Z 2022-03-23T08:18:47Z 2022-01-25 info:eu-repo/semantics/article Fernández-Ochoa, Á... [et al.]. Recent Analytical Approaches for the Study of Bioavailability and Metabolism of Bioactive Phenolic Compounds. Molecules 2022, 27, 777. [https://doi.org/10.3390/molecules27030777] http://hdl.handle.net/10481/73655 10.3390/molecules27030777 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI