The Arginine Catabolism-Derived Amino Acid L-ornithine Is a Chemoattractant for Pseudomonas aeruginosa Dhodary, Basanta Sampedro Quesada, María Inmaculada Chemotaxis L-ornithine Pseudomonas aeruginosa Chemoreceptor This research was funded, in part, by the United States Cystic Fibrosis Foundation (Hill16I0). Pseudomonas aeruginosa is a common, opportunistic bacterial pathogen among patients with cystic fibrosis, asthma, and chronic obstructive pulmonary disease. During the course of these diseases, L-ornithine, a non-proteinogenic amino acid, becomes more abundant. P. aeruginosa is chemotactic towards other proteinogenic amino acids. Here, we evaluated the chemotaxis response of P. aeruginosa towards L-ornithine. Our results show that L-ornithine serves as a chemoattractant for several strains of P. aeruginosa, including clinical isolates, and that the chemoreceptors involved in P. aeruginosa PAO1 are PctA and PctB. It seems likely that P. aeruginosa’s chemotactic response to L-ornithine might be a common feature and thus could potentially contribute to pathogenesis processes during colonization and infection scenarios. 2022-03-23T07:42:52Z 2022-03-23T07:42:52Z 2022-01-24 info:eu-repo/semantics/article Dhodary, B... [et al.]. The Arginine Catabolism- Derived Amino Acid L-ornithine Is a Chemoattractant for Pseudomonas aeruginosa. Microorganisms 2022, 10, 264. [https://doi.org/10.3390/microorganisms10020264] http://hdl.handle.net/10481/73652 10.3390/microorganisms10020264 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI