‘Physio-EndEA’ Study: A Randomized, Parallel-Group Controlled Trial to Evaluate the Effect of a Supervised and Adapted Therapeutic Exercise Program to Improve Quality of Life in Symptomatic Women Diagnosed with Endometriosis Salinas Asensio, María del Mar Ocón Hernández, Olga Mundo López, Antonio Fernández Lao, Carolina Peinado Rodríguez, Francisco Manuel Padilla Vinuesa, Carmen Postigo Martín, Elisa Paula Lozano Lozano, Mario Lara Ramos, Ana Arroyo Morales, Manuel Cantarero Villanueva, Irene Artacho Cordón, Francisco Endometriosis Physiotherapy Therapeutic exercise Quality of life Motor control Pain This research was funded by the Health Institute Carlos III (FEDER funds), grant number PI17/01743, and donations from particular endometriosis women that believed in this project from the beginning. It was also partly supported by funds from the PAIDI group CTS-206 (Oncologia Basica y Clinica). This study takes place thanks to the additional funding from the University of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES). Aim: The ‘Physio-EndEA’ study aims to explore the potential benefits of a therapeutic exercise program (focused on lumbopelvic stabilization and tolerance to exertion) on the health-related quality of life (HRQoL) of symptomatic endometriosis women. Design: The present study will use a parallel-group randomized controlled trial design. Methods: A total of 22 symptomatic endometriosis women will be randomized 1:1 to the Physio-EndEA or usual care groups. The ‘Physio-EndEA’ program will consist of a one-week lumbopelvic stabilization learning phase followed by an eight-week phase of stretching, aerobic and resistance exercises focused on the lumbopelvic area that will be sequentially instructed and supervised by a trained physiotherapist (with volume and intensity progression) and adapted daily to the potential of each participant. The primary outcome measure is HRQoL. The secondary outcome measures included clinician-reported outcomes (pressure pain thresholds, muscle thickness and strength, flexibility, body balance and cardiorespiratory fitness) and patient-reported outcomes (pain intensity, physical fitness, chronic fatigue, sexual function, gastrointestinal function and sleep quality). Discussion: Findings of this study will help to identify cost-effective non-pharmacological options (such as this exercise-based intervention) that may contribute to the improvement of HRQoL in symptomatic endometriosis women. 2022-03-22T13:19:55Z 2022-03-22T13:19:55Z 2022-02-02 info:eu-repo/semantics/article Salinas-Asensio, M.d.M... [et al.]. ‘Physio- EndEA’ Study: A Randomized, Parallel-Group Controlled Trial to Evaluate the Effect of a Supervised and Adapted Therapeutic Exercise Program to Improve Quality of Life in SymptomaticWomen Diagnosed with Endometriosis. Int. J. Environ. Res. Public Health 2022, 19, 1738. [https://doi.org/10.3390/ijerph19031738] http://hdl.handle.net/10481/73635 10.3390/ijerph19031738 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI