Plasma Levels of Bile Acids Are Related to Cardiometabolic Risk Factors in Young Adults Osuna Prieto, Francisco Javier Rubio López, José Ruiz Ruiz, Jonatan Martínez Téllez, Borja Manuel Biomarkers Cardiometabolic Risk Brown adipose tissue Dyslipidemia Insulin resistance The study was supported by the Spanish Ministry of Economy and Competitiveness via Retos de la Sociedad (DEP2016-79512-R to J.R.R.) and European Regional Development Funds (ERDF), the Spanish Ministry of Education (FPU 16/02828), the University of Granada Plan Propio de Investigacion 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades (ERDF: ref. SOMM17/6107/UGR), The Netherlands CardioVascular Research Initiative "the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences" (CVON2017-20 GENIUS-2) to P.C.N.R., and the Chinese Scholarship Council (CSC; No. 201707060012 to X.D., No. 201607060017 to W.Y.). B.M.T. is supported by an individual postdoctoral grant from the Fundacion Alfonso Martin Escudero. Context: Bile acids (BA) are known for their role in intestinal lipid absorption and can also play a role as signaling molecules to control energy metabolism. Prior evidence suggests that alterations in circulating BA levels and in the pool of circulating BA are linked to an increased risk of obesity and a higher incidence of type 2 diabetes in middleaged adults. Objective: We aimed to investigate the association between plasma levels of BA with cardiometabolic risk factors in a cohort of well-phenotyped, relatively healthy young adults. Methods: Body composition, brown adipose tissue, serum classical cardiometabolic risk factors, and a set of 8 plasma BA (including glyco-conjugated forms) in 136 young adults (age 22.1 ± 2.2 years, 67% women) were measured. Results: Plasma levels of chenodeoxycholic acid (CDCA) and glycoursodeoxycholic acid (GUDCA) were higher in men than in women, although these differences disappeared after adjusting for body fat percentage. Furthermore, cholic acid (CA), CDCA, deoxycholic acid (DCA), and glycodeoxycholic acid (GDCA) levels were positively, yet weakly associated, with lean body mass (LBM) levels, while GDCA and glycolithocholic acid (GLCA) levels were negatively associated with 18F-fluorodeoxyglucose uptake by brown adipose tissue. Interestingly, glycocholic acid (GCA), glycochenodeoxycholic acid (GCDCA), and GUDCA were positively associated with glucose and insulin serum levels, HOMA index, low-density lipoprotein cholesterol, tumor necrosis factor alpha, interleukin (IL)-2, and IL-8 levels, but negatively associated with high-density lipoprotein cholesterol, ApoA1, and adiponectin levels, yet these significant correlations partially disappeared after the inclusion of LBM as a confounder. Conclusion: Our findings indicate that plasma levels of BA might be sex dependent and are associated with cardiometabolic and inflammatory risk factors in young and relatively healthy adults. 2022-03-21T08:15:03Z 2022-03-21T08:15:03Z 2021-10-26 journal article Francisco J Osuna-Prieto... [et al.]. Plasma Levels of Bile Acids Are Related to Cardiometabolic Risk Factors in Young Adults, The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 3, March 2022, Pages 715–723, [https://doi.org/10.1210/clinem/dgab773] http://hdl.handle.net/10481/73585 10.1210/clinem/dgab773 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España Oxford University Press