Variations in the Composition, Antioxidant and Antimicrobial Activities of Cystoseira compressa during Seasonal Growth Cagalj, Martina Razola Díaz, María del Carmen Verardo, Vito Cystoseira compressa Microwave-assisted extraction Green extraction Biological activity Seaweed Seasonal variations Nutraceuticals Fatty acids This research is supported by the PRIMA program under project BioProMedFood (Project ID 1467). The PRIMA programme is supported by the European Union. The underexplored biodiversity of seaweeds has recently drawn great attention from researchers to find the bioactive compounds that might contribute to the growth of the blue economy. In this study, we aimed to explore the effect of seasonal growth (from May to September) on the in vitro antioxidant (FRAP, DPPH, and ORAC) and antimicrobial effects (MIC and MBC) of Cystoseira compressa collected in the Central Adriatic Sea. Algal compounds were analyzed by UPLC-PDA-ESI-QTOF, and TPC and TTC were determined. Fatty acids, among which oleic acid, palmitoleic acid, and palmitic acid were the dominant compounds in samples. The highest TPC, TTC and FRAP were obtained for June extract, 83.4 +/- 4.0 mg GAE/g, 8.8 +/- 0.8 mg CE/g and 2.7 +/- 0.1 mM TE, respectively. The highest ORAC value of 72.1 +/- 1.2 mu M TE was obtained for the August samples, and all samples showed extremely high free radical scavenging activity and DPPH inhibition (>80%). The MIC and MBC results showed the best antibacterial activity for the June, July and August samples, when sea temperature was the highest, against Listeria monocytogenes, Staphylococcus aureus, and Salmonella enteritidis. The results show C. compressa as a potential species for the industrial production of nutraceuticals or functional food ingredients. 2022-02-15T12:46:27Z 2022-02-15T12:46:27Z 2022-01-11 info:eu-repo/semantics/article Cagalj, M... [et al.]. Variations in the Composition, Antioxidant and Antimicrobial Activities of Cystoseira compressa during Seasonal Growth. Mar. Drugs 2022, 20, 64. [https://doi.org/10.3390/md20010064] http://hdl.handle.net/10481/72850 10.3390/md20010064 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI