Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds Giampieri, Francesca Quiles Morales, José Luis Orantes Bermejo, Francisco José Honeybee byproducts Bee pollen Propolis Bee bread Royal jelly Beeswax Beside honey, honeybees (Apis mellifera L.) are able to produce many byproducts, including bee pollen, propolis, bee bread, royal jelly, and beeswax. Even if the medicinal properties of these byproducts have been recognized for thousands of years by the ancient civilizations, in the modern era, they have a limited use, essentially as nutritional supplements or health products. However, these natural products are excellent sources of bioactive compounds, macro- and micronutrients, that, in a synergistic way, confer multiple biological activities to these byproducts, such as, for example, antimicrobial, antioxidant, and anti-inflammatory properties. This work aims to update the chemical and phytochemical composition of bee pollen, propolis, bee bread, royal jelly, and beeswax and to summarize the main effects exerted by these byproducts on human health, from the anticancer and immunemodulatory activities to the antidiabetic, hypolipidemic, hypotensive, and anti-allergic properties. 2022-02-02T09:01:36Z 2022-02-02T09:01:36Z 2022-01-02 journal article Giampieri, F... [et al.] (2022). Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds. Journal of agricultural and food chemistry. [https://doi.org/10.1021/acs.jafc.1c05822] http://hdl.handle.net/10481/72603 10.1021/acs.jafc.1c05822 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España American Chemical Society