Brain Asymmetry: Towards an Asymmetrical Neurovisceral Integration Ramírez Sánchez, Manuel Domínguez Vías, German Neurochemical asymmetry Functional asymmetry Neurovisceral integration Neuropeptides Neuropeptidases This review was supported by the group of the University of Jaen "Neuroendocrinology and Nutrition" BIO-221. Despite the ancestral evidence of an asymmetry in motor predominance, going through the inspiring discoveries of Broca and Wernicke on the localization of language processing, continuing with the subsequent noise coinciding with the study of brain function in commissurotomized patients—and the subsequent avalanche of data on the asymmetric distribution of multiple types of neurotransmitters in physiological and pathological conditions—even today, the functional significance of brain asymmetry is still unknown. Currently, multiple evidence suggests that functional asymmetries must have a neurochemical substrate and that brain asymmetry is not a static concept but rather a dynamic one, with intra- and inter-hemispheric interactions between its various processes, and that it is modifiable depending on changing endogenous and environmental conditions. Furthermore, based on the concept of neurovisceral integration in the overall functioning of an organism, some evidence has emerged suggesting that this integration could be organized asymmetrically, using the autonomic nervous system as a bidirectional communication pathway, whose performance would also be asymmetric. However, the functional significance of this distribution, as well as the evolutionary advantage of an asymmetric nervous organization, is still unknown. 2022-02-01T13:35:26Z 2022-02-01T13:35:26Z 2021-12-13 info:eu-repo/semantics/article Ramírez-Sánchez, M... [et al.]. Brain Asymmetry: Towards an Asymmetrical Neurovisceral Integration. Symmetry 2021, 13, 2409. [https://doi.org/10.3390/sym13122409] http://hdl.handle.net/10481/72596 10.3390/sym13122409 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI