Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects Haverinen, Elsi Fernández Cabrera, Mariana Fátima Mustieles Miralles, Vicente Metabolic syndrome Endocrine disrupting chemicals Human biomonitoring HBM4EU Obesity Insulin resistance Diabetes Dyslipidemia Hypertension The HBM4EU project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 733032. Increasing prevalence of metabolic syndrome (MetS) is causing a significant health burden among the European population. Current knowledge supports the notion that endocrine-disrupting chemicals (EDCs) interfere with human metabolism and hormonal balance, contributing to the conventionally recognized lifestyle-related MetS risk factors. This review aims to identify epidemiological studies focusing on the association between MetS or its individual components (e.g., obesity, insulin resistance, diabetes, dyslipidemia and hypertension) and eight HBM4EU priority substances (bisphenol A (BPA), per- and polyfluoroalkyl substances (PFASs), phthalates, polycyclic aromatic hydrocarbons (PAHs), pesticides and heavy metals (cadmium, arsenic and mercury)). Thus far, human biomonitoring (HBM) studies have presented evidence supporting the role of EDC exposures on the development of individual MetS components. The strength of the association varies between the components and EDCs. Current evidence on metabolic disturbances and EDCs is still limited and heterogeneous, and mainly represent studies from North America and Asia, highlighting the need for well-conducted and harmonized HBM programmes among the European population. Rigorous and ongoing HBM in combination with health monitoring can help to identify the most concerning EDC exposures, to guide future risk assessment and policy actions. 2022-01-31T11:42:11Z 2022-01-31T11:42:11Z 2021-12-10 info:eu-repo/semantics/article Haverinen, E... [et al.]. Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects. Int. J. Environ. Res. Public Health 2021, 18, 13047. [https://doi.org/10.3390/ijerph182413047] http://hdl.handle.net/10481/72559 10.3390/ijerph182413047 eng info:eu-repo/grantAgreement/EC/H2020/733032 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI