A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against A beta-induced toxicity in C. elegans García García, Amalia Rojas Macías, Sara Rivas García, Lorenzo Navarro Hortal, María Dolores Romero Márquez, José Manuel Choquesillo Lazarte, Duane Salinas Castillo, Alfonso Quiles Morales, José Luis Rodríguez Diéguez, Antonio The authors gratefully acknowledge funding support from the Spanish Ministry of Science, Innovation and Universities (PGC2018-102052-B-C21 and PID2020-116460RB-I00) and the Junta de Andaluci ' a (FQM-394 and FQM-134). The authors gratefully acknowledge the funding support of FEDER/Junta de Andaluci ' a Consejeri ' a de Economi ' a y Conocimiento, Grant B-AGR-193-UGR18. O. L. and J. G. F. B. also thank Grant PID2020-116460RB-I00 funded by MCIN/AEI/10.13039/50110 0011033. S. R. acknowledge the Juan de la Cierva Fellowship (IJC2019-038894-I). Mari ' a D. Navarro-Hortal and Jose M. Romero-Ma ' rquez are FPU fellows from the Spanish Ministry of Educacio ' n y Formacio ' n Profesional. A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)(2)] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against A beta-induced toxicity in the Caenorhabditis elegans model, which has never been reported. 2022-01-31T07:34:50Z 2022-01-31T07:34:50Z 2021-12-16 info:eu-repo/semantics/article Chem. Commun., 2022, Advance Article. DOI: [10.1039/d1cc04404d] http://hdl.handle.net/10481/72538 10.1039/d1cc04404d eng http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial 3.0 España Royal Society of Chemistry