Long-Term Nightshift Work and Breast Cancer Risk: An Updated Systematic Review and Meta-Analysis with Special Attention to Menopausal Status and to Recent Nightshift Work Pérez-Gómez, Beatriz Jiménez Moleón, José Juan Nightshift work Breast cancer Recent exposure Meta-analysis Menopausal status Occupational exposure Retirement age Conceptualization, B.P.-G., C.S. and A.M.P.-F.; methodology, B.P.-G., A.M.P.-F. and C.S. validation, B.P.-G., N.F.d.L., R.P.-B. and V.L; formal analysis, A.M.P.-F., R.P.-B. and C.S.; investigation, A.M.P.-F., R.P.-B. and C.S. resources, B.P.-G. and M.P., data curation, A.M.P.-F. and C.S.; writing—original draft preparation, C.S. and B.P.-G.; writing—review and editing R.P.-B., V.L., N.F.d.L., J.J.J.-M. and M.P.; visualization, A.M.P.-F., B.P.-G., R.P.-B. and C.S.; supervision, B.P.-G., M.P. and J.J.J.-M.; project administration, B.P.-G. All authors have read and agreed to the published version of the manuscript. This systematic review discusses long-term NSW and female BC risk, with special attention to differences between pre-and postmenopausal BC, to test the association with recent NSW. The review follows PRISMA guidelines (Prospero registry: CRD42018102515). We searched PubMed, Embase, and WOS for case–control, nested case–control, and cohort studies addressing long-term NSW (≥15 years) as risk exposure and female BC as outcome until 31 December 2020. Risk of bias was evaluated with the Newcastle–Ottawa scale. Eighteen studies were finally in-cluded (eight cohorts; five nested case–control; five case–control). We performed meta-analyses on long-term NSW and BC risk; overall and by menopausal status; a subanalysis on recent long-term NSW, based on studies involving predominantly women below retirement age; and a dose– response meta-analysis on NSW duration. The pooled estimate for long-term NSW and BC was 1.13 (95%CI = 1.01–1.27; 18 studies, I2 = 56.8%, p = 0.002). BC risk increased 4.7% per 10 years of NSW (95%CI = 0.94–1.09; 16 studies, I2 = 33.4%, p = 0.008). The pooled estimate for premenopausal BC was 1.27 (95%CI = 0.96–1.68; six studies, I2 = 32.0%, p = 0.196) and for postmenopausal BC 1.05 (95%CI = 0.90–1.24, I2 = 52.4%; seven studies, p = 0.050). For recent long-term exposure, the pooled estimate was 1.23 (95%CI = 1.06–1.42; 15 studies; I2 = 48.4%, p = 0.018). Our results indicate that long-term NSW increases the risk for BC and that menopausal status and time since exposure might be relevant. 2021-12-20T10:40:37Z 2021-12-20T10:40:37Z 2021-11-26 info:eu-repo/semantics/article Schwarz, C.; Pedraza-Flechas, A.M.; Pastor-Barriuso, R.; Lope, V.; de Larrea, N.F.; Jiménez-Moleón, J.J.; Pollán, M.; Pérez-Gómez, B. Long-Term Nightshift Work and Breast Cancer Risk: An Updated Systematic Review and Meta-Analysis with Special Attention to Menopausal Status and to Recent Nightshift Work. Cancers 2021, 13, 5952. [https://doi.org/10.3390/cancers13235952] http://hdl.handle.net/10481/72130 10.3390/cancers13235952 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI