Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma Manzano Moreno, Francisco Javier Costela Ruiz, Víctor Javier García Recio, Enrique Olmedo Gaya, María Victoria Ruiz Rodríguez, Concepción Reyes Botella, Candelaria Salivary biomarker MicroRNA Cytokines Oral pathology Diagnosis Oral cancer This study was supported by research group BIO277 (Junta de Andalucia), Department of Nursing (University of Granada) and Department of Stomatology (University of Granada) Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs. 2021-12-13T11:19:26Z 2021-12-13T11:19:26Z 2021-11-11 journal article Manzano-Moreno, F.J.; Costela-Ruiz, V.J.; García-Recio, E.; Olmedo-Gaya, M.V.; Ruiz, C.; Reyes-Botella, C. Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma. Int. J. Mol. Sci. 2021, 22, 12215. [https:// doi.org/10.3390/ijms222212215] http://hdl.handle.net/10481/72040 10.3390/ijms222212215 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI