<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/72039">
      <dc:title>Human adipose tissue–derived mesenchymal stromal cells and  their phagocytic capacity</dc:title>
      <dc:creator>Costela Ruiz, Víctor Javier</dc:creator>
      <dc:creator>Melguizo Rodríguez, Lucía Raquel</dc:creator>
      <dc:creator>Illescas Montes, Rebeca</dc:creator>
      <dc:creator>García Recio, Enrique</dc:creator>
      <dc:creator>Arias Santiago, Salvador Antonio</dc:creator>
      <dc:creator>Ruiz Rodríguez, Concepción</dc:creator>
      <dc:creator>Luna Bertos, María Elvira De</dc:creator>
      <dc:subject>Immunogenicity</dc:subject>
      <dc:subject>Infection</dc:subject>
      <dc:subject>Phagocytosis</dc:subject>
      <dc:subject>Stem cell-microenvironment interactions</dc:subject>
      <dc:subject>Stromal cells</dc:subject>
      <dc:description>This study was supported by Research Group BIO277 (Junta de Andalucia), the Department of Nursing of the University of Granada and The Cell Production Unit of the Virgen de las Nieves Hospital of Granada (Servicio Andaluz de Salud).</dc:description>
      <dc:description>Mesenchymal stromal cells (MSCs) have evidenced considerable therapeutic potential in numerous clinical fields, especially in tissue regeneration. The immunological characteristics of this cell population include the expression of Toll-like receptors and mannose receptors, among others. The study objective was to determine whether MSCs have phagocytic capacity against different target particles. We isolated and characterized three human adipose tissue MSC (HAT-MSC) lines from three patients and analysed their phagocytic capacity by flow cytometry, using fluorescent latex beads, and by transmission electron microscopy, using Escherichia coli, Staphylococcus aureus and Candida albicans as biological materials and latex beads as non-biological material. The results demonstrate that HAT-MSCs can phagocyte particles of different nature and size. The percentage of phagocytic cells ranged between 33.8% and 56.2% (mean of 44.37% +/- 11.253) according to the cell line, and a high phagocytic index was observed. The high phagocytic capacity observed in MSCs, which have known regenerative potential, may offer an advance in the approach to certain local and systemic infections.</dc:description>
      <dc:date>2021-12-13T11:16:25Z</dc:date>
      <dc:date>2021-12-13T11:16:25Z</dc:date>
      <dc:date>2021-12-02</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Costela Ruiz VJ, Melguizo Rodríguez  L, Illescas Montes R, et al. Human adipose tissue–derived  mesenchymal stromal cells and their phagocytic capacity. J  Cell Mol Med. 2021;00:1–8. [doi:10.1111/jcmm.17070]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/72039</dc:identifier>
      <dc:identifier>10.1111/jcmm.17070</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>Wiley Online Library</dc:publisher>
   </ow:Publication>
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