An overview of the synaptic vesicle lipid composition Binotti, Beyenech Jahn, Reinhard Pérez Lara, Francisco Ángel Lipid composition Synaptic vesicles Neurotransmitter release Exocytosis Endocytosis This work was funded by a Ramon y Cajal grant to A.P-L. (RYC2018-023837-I) and by a grant from the National Institutes of Health to R.J. (P01 GM072694) . Chemical neurotransmission is the major mechanism of neuronal communication. Neurotransmitters are released from secretory organelles, the synaptic vesicles (SVs) via exocytosis into the synaptic cleft. Fusion of SVs with the presynaptic plasma membrane is balanced by endocytosis, thus maintaining the presynaptic membrane at steadystate levels. The protein machineries responsible for exo-and endocytosis have been extensively investigated. In contrast, less is known about the role of lipids in synaptic transmission and how the lipid composition of SVs is affected by dynamic exo-endocytotic cycling. Here we summarize the current knowledge about the composition, organization, and function of SV membrane lipids. We also cover lipid biogenesis and maintenance during the synaptic vesicle cycle. 2021-12-07T09:23:45Z 2021-12-07T09:23:45Z 2021-09-30 journal article B. Binotti et al. An overview of the synaptic vesicle lipid composition. Archives of Biochemistry and Biophysics 709 (2021) 108966. [https://doi.org/10.1016/j.abb.2021.108966] http://hdl.handle.net/10481/71911 10.1016/j.abb.2021.108966 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España Elsevier