Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort Gil Rodríguez, Jaime Martos Ruiz, Michel Peregrina Rivas, José Antonio Aranda Laserna, Pablo Benavente Fernández, Alberto Guirao Arrabal, Emilio Melchor Rodríguez, Juan Manuel SARS-CoV-2 COVID-19 Lung Ultrasound Early warning score At the moment, several COVID-19 scoring systems have been developed. It is necessary to determine which one better predicts a poor outcome of the disease. We conducted a single-center prospective cohort study to validate four COVID-19 prognosis scores in adult patients with confirmed infection at ward. These are National Early Warning Score (NEWS) 2, Lung Ultrasound Score (LUS), COVID-19 Worsening Score (COWS), and Spanish Society of Infectious Diseases and Clinical Microbiology score (SEIMC Score). Our outcomes were the combined variable “poor outcome” (noninvasive mechanical ventilation, intubation, intensive care unit admission, and death at 28 days) and death at 28 days. Scores were analysed using univariate logistic regression models, receiver operating characteristic curves, and areas under the curve. Eighty-one patients were included, from which 21 had a poor outcome, and 9 died. We found a statistically significant correlation between poor outcome and NEWS2, LUS > 15, and COWS. Death at 28 days was statistically correlated with NEWS2 and SEIMC Score although COWS also performs well. NEWS2, LUS, and COWS accurately predict poor outcome; and NEWS2, SEIMC Score, and COWS are useful for anticipating death at 28 days. Lung ultrasound is a diagnostic tool that should be included in COVID-19 patients evaluation. 2021-11-29T08:32:24Z 2021-11-29T08:32:24Z 2021 journal article Gil-Rodríguez, J.; Martos-Ruiz, M.; Peregrina-Rivas, J.-A.; Aranda-Laserna, P.; Benavente-Fernández, A.; Melchor, J.; Guirao-Arrabal, E. Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort. Diagnostics 2021, 11, 2211. https:// doi.org/10.3390/diagnostics11122211 http://hdl.handle.net/10481/71801 10.3390/diagnostics11122211 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI