In vitro Leishmanicidal and Trypanosomicidal Properties of Imidazole-Containing Azine and Benzoazine Derivatives Martín Montes, Álvaro Miguel Marín Sánchez, Clotilde Rosales Lombardo, María José Sánchez Moreno, Manuel Azines and benzoazines Imidazole In vitro trypanosomicidal and leishmanicidal activity Fe-SOD inhibition The authors thank the MCINN Project CTQ2009-14288-C04-01 for financial support. We are also grateful to the NMR and Elemental Analysis C.A.I.s of the Universidad Complutense (Madrid), and to the Transmission-electron microscopy and Nuclear magnetic resonance spectroscopy services of the CIC-University of Granada. Leishmaniasis and Chagas diseases are two of the most important parasitic diseases in the world. Both belong to the category of Neglected Tropical Diseases, and they cannot be prevented by vaccination. Their treatments are founded in outdated drugs that possess many pernicious side-effects and they’re not easy to administer. With the aim of discovering new compounds that could serve as anti-trypanosomal drugs, an antiparasitic study of a synthetic compound family has been conducted. A series of new 1,4-bis(alkylamino)- and 1- alkylamino-4-chloroazine and benzoazine derivatives 1–4 containing imidazole rings have been synthesized and identified. Their structures showed a possible interest based on previous work. Their in vitro anti-Leishmania infantum, anti-L. braziliensis, anti-L. donovani and anti-T. cruzi activity were tested, as well as the inhibition of Fe-SOD enzymes. It was found that some of them exhibited quite relevant values indicative of being worthy of future more detailed studies, as most of them showed activity to more than only one parasite species, especially compound 3c was active for the three studied Leishmania species and also for T. cruzi, which is a very interesting trait as it covers a wide spectrum. 2021-11-10T09:58:30Z 2021-11-10T09:58:30Z 2021-10-19 info:eu-repo/semantics/article Martín-Montes, Á... [et al.] (2021), In vitro Leishmanicidal and Trypanosomicidal Properties of Imidazole-Containing Azine and Benzoazine Derivatives. ChemMedChem. [https://doi.org/10.1002/cmdc.202100413] http://hdl.handle.net/10481/71408 10.1002/cmdc.202100413 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España Wiley-VCH Verlag GmbH