Challenges and Scientific Prospects of the Newest Generation of mRNA-Based Vaccines against SARS-CoV-2 Calina, D. Hernández Jérez, Antonio Francisco COVID-19 pandemic Public health Coronaviruses mRNA vaccines Side effects Conceptualization D.C., A.F.H., T.H.; Data curation A.O.D.; Formal analysis A.M.E., B.N.I., P.G.V., A.T.; Methodology T.K.N., A.O.D.; Supervision D.C., A.F.H., T.H., A.T.; Valida tion D.C., A.T., P.G.V.; Writing—original draft all authors; Writing—review & editing D.C., A.F.H., T.H. All authors have read and agreed to the published version of the manuscript. In the context of the current COVID-19 pandemic, traditional, complex and lengthy methods of vaccine development and production would not have been able to ensure proper management of this global public health crisis. Hence, a number of technologies have been developed for obtaining a vaccine quickly and ensuring a large scale production, such as mRNA-based vaccine platforms. The use of mRNA is not a new concept in vaccine development but has leveraged on previous knowledge and technology. The great number of human resources and capital investements for mRNA vaccine development, along with the experience gained from previous studies on infectious diseases, allowed COVID-19 mRNA vaccines to be developed, conditionally approved and commercialy available in less than one year, thanks to decades of basic research. This review critically presents and discusses the COVID-19 mRNA vaccine-induced immunity, and it summarizes the most common anaphylactic and autoimmune adverse effects that have been identified until now after massive vaccination campaigns. 2021-10-22T12:10:17Z 2021-10-22T12:10:17Z 2021-08-31 info:eu-repo/semantics/article Calina, D.; Hernández, A.F.; Hartung, T.; Egorov, A.M.; Izotov, B.N.; Nikolouzakis, T.K.; Tsatsakis, A.; Vlachoyiannopoulos, P.G.; Docea, A.O. Challenges and Scientific Prospects of the Newest Generation of mRNA-Based Vaccines against SARS-CoV-2. Life 2021, 11, 907. [https://doi.org/10.3390/ life11090907] http://hdl.handle.net/10481/71056 10.3390/ life11090907 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI