<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/71008">
      <dc:title>Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats</dc:title>
      <dc:creator>Robles Vera, Iñaki</dc:creator>
      <dc:creator>de la Visitación, Néstor</dc:creator>
      <dc:creator>Toral, Marta</dc:creator>
      <dc:creator>Sánchez Santos, Manuel</dc:creator>
      <dc:creator>Romero Pérez, Miguel</dc:creator>
      <dc:creator>Gómez Guzmán, Manuel</dc:creator>
      <dc:creator>Vargas Palomares, José Félix</dc:creator>
      <dc:creator>Duarte Pérez, Juan Manuel</dc:creator>
      <dc:creator>Jiménez Moleón, Rosario</dc:creator>
      <dc:subject>Doxycycline</dc:subject>
      <dc:subject>Gut dysbiosis</dc:subject>
      <dc:subject>Hypertension</dc:subject>
      <dc:subject>Oxidative stress</dc:subject>
      <dc:subject>Inflammation</dc:subject>
      <dc:subject>(Deoxycorticosterone acetate) DOCA-salt model</dc:subject>
      <dc:description>Previous experiments in animals and humans show that shifts in microbiota and its&#xd;
metabolites are linked to hypertension. The present study investigates whether doxycycline (DOX,&#xd;
a broad-spectrum tetracycline antibiotic) improves dysbiosis, prevent cardiovascular pathology and&#xd;
attenuate hypertension in deoxycorticosterone acetate (DOCA)-salt rats, a renin-independent model&#xd;
of hypertension. Male Wistar rats were randomly assigned to three groups: control, DOCA-salt&#xd;
hypertensive rats, DOCA-salt treated with DOX for 4 weeks. DOX decreased systolic blood pressure,&#xd;
improving endothelial dysfunction and reducing aortic oxidative stress and inflammation. DOX&#xd;
decreased lactate-producing bacterial population and plasma lactate levels, improved gut barrier&#xd;
integrity, normalized endotoxemia, plasma noradrenaline levels and restored the Treg content in aorta.&#xd;
These data demonstrate that DOX through direct effects on gut microbiota and its non-microbial&#xd;
effects (anti-inflammatory and immunomodulatory) reduces endothelial dysfunction and the increase&#xd;
in blood pressure in this low-renin form of hypertension.</dc:description>
      <dc:date>2021-10-20T09:33:39Z</dc:date>
      <dc:date>2021-10-20T09:33:39Z</dc:date>
      <dc:date>2021</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Robles-Vera, I.; de la Visitación, N.; Toral, M.; Sánchez, M.; Romero, M.; Gómez-Guzmán, M.; Vargas, F.; Duarte, J.; Jiménez, R. Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats. Nutrients 2021, 13, 2971. https:// doi.org/10.3390/nu13092971</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/71008</dc:identifier>
      <dc:identifier>10.3390/nu13092971</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>