Effect of Propolis Paste and Mouthwash Formulation on Healing after Teeth Extraction in Periodontal Disease Lisbona González, María Jesús Muñoz Soto, Esther Lisbona González, Cristina Vallecillo Rivas, Marta Díaz Castro, Javier Moreno Fernández, Jorge Periodontal disease Propolis Chlorhexidine Teeth extraction Oral healing Jorge Moreno-Fernandez was supported by a Postdoctoral Contract (Contrato Puente) from the University of Granada and Maria Jesus Lisbona-Gonzalez thanks to the doctoral program in clinical medicine and public health. This study investigated the antimicrobial effects of a mouthwash containing propolis and the effect of a propolis paste formulation on dental healing after teeth extraction in patients with periodontal disease. In the mouthwash experience, the population comprised 40 patients, which were divided as follows: the control mouthwash, 0.2% chlorhexidine (v/v) mouthwash, 2% (w/v) propolis mouthwash, and propolis + chlorhexidine mouthwash. The study of the propolis paste comprised a population of 60 patients with periodontal disease, and a total of 120 symmetric tooth extractions were performed. Propolis showed antimicrobial activity by itself, and especially with the chlorhexidine association. Three days after surgery in the teeth treated with control paste, only 13.4% had completely healed; however, with propolis paste, in 90% of the periodontal sockets, healing was complete. In addition, a reduction in Streptococci mutans and Lactobacilli cfu was observed with propolis, and especially with the association of chlorhexidine + propolis. Propolis mouthwash reduced bacterial proliferation, especially in association with chlorhexidine. Propolis paste is a viable alternative for socket healing after dental extraction. The knowledge gained from these findings will provide a foundation for similar propolis therapies in order to improve the healing process after dental surgery. 2021-10-08T07:39:02Z 2021-10-08T07:39:02Z 2021-08-04 info:eu-repo/semantics/article Lisbona-González, M.J... [et al.]. Effect of Propolis Paste and Mouthwash Formulation on Healing after Teeth Extraction in Periodontal Disease. Plants 2021, 10, 1603. [https://doi.org/10.3390/plants10081603] http://hdl.handle.net/10481/70740 10.3390/plants10081603 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI