<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/70728">
      <dc:title>In Vitro Wound-Healing Properties of Water-Soluble Terpenoids Loaded on Halloysite Clay</dc:title>
      <dc:creator>Marinelli, Lisa</dc:creator>
      <dc:creator>Borrego Sánchez, Ana María</dc:creator>
      <dc:creator>García Villén, Fátima</dc:creator>
      <dc:creator>Viseras Iborra, César Antonio</dc:creator>
      <dc:subject>Clay</dc:subject>
      <dc:subject>Halloysite</dc:subject>
      <dc:subject>Skin regeneration</dc:subject>
      <dc:subject>Terpenoids</dc:subject>
      <dc:subject>Wound healing</dc:subject>
      <dc:description>This research was funded by the Italian Ministry of Education, University and Research (University "G. d'Annunzio" of Chieti-Pescara), grant number FAR 2020.</dc:description>
      <dc:description>Recently, mineral healing clays have gained much attention for wound-dressing applications.&#xd;
Here, we selected halloysite (HAL) clay as a biocompatible, non-toxic material that is useful&#xd;
as a drug delivery system to enhance the healing properties of water-soluble terpenoids 1-3 (T1-3).&#xd;
Terpenoids-loaded HAL clay (TH1-3) was prepared and characterized by adsorption equilibrium&#xd;
studies, X-ray powder diffraction (XRPD), thermogravimetric analysis (TGA), differential scanning&#xd;
calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy, and release studies. The results&#xd;
reveal that T1-3 were adsorbed at the HAL surface with good efficiency. The prevalent mechanism&#xd;
of drug retention is due to the adsorption via electrostatic interactions between the cationic groups&#xd;
of the T1-3 and the HAL’s external surface. Release studies demonstrated that T3 was released&#xd;
in a higher percentage (>60%) compared to T1-2 ( 50%). Additionally, TH1-3 were assessed for&#xd;
their antimicrobial activity and capability to promote the re-epithelialization of scratched HaCat&#xd;
monolayers, through the time-kill test and the wound-healing assays, respectively. The results reveal&#xd;
that all the tested formulations were able to reduce the microbial growth after 1 h of incubation and&#xd;
that they ensured complete wound closure after 48 h. Furthermore, at the concentration of 1  g/mL,&#xd;
TH3 exhibited 45% wound closure at 24 h, compared to TH1 (27%) and TH2 (30%), proving to be the&#xd;
best candidate in making the tissue-repair process easier and faster.</dc:description>
      <dc:date>2021-10-07T12:32:10Z</dc:date>
      <dc:date>2021-10-07T12:32:10Z</dc:date>
      <dc:date>2021-07-22</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Marinelli, L... [et al.]. In Vitro Wound-Healing Properties of Water-Soluble Terpenoids Loaded on Halloysite Clay. Pharmaceutics 2021, 13, 1117. [https://doi.org/10.3390/pharmaceutics13081117]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/70728</dc:identifier>
      <dc:identifier>10.3390/pharmaceutics13081117</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>