<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/70563">
      <dc:title>Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review</dc:title>
      <dc:creator>Montero Vílchez, Trinidad</dc:creator>
      <dc:creator>Sierra Sánchez, Álvaro</dc:creator>
      <dc:creator>Sánchez Diaz, Manuel</dc:creator>
      <dc:creator>Quiñones Vico, María Isabel</dc:creator>
      <dc:creator>Sanabria de la Torre, Raquel</dc:creator>
      <dc:creator>Martínez López, Antonio</dc:creator>
      <dc:creator>Arias Santiago, Salvador Antonio</dc:creator>
      <dc:subject>Advanced therapy</dc:subject>
      <dc:subject>Conditioned medium</dc:subject>
      <dc:subject>Dermatology</dc:subject>
      <dc:subject>Mesenchymal stem cells</dc:subject>
      <dc:subject>Stem cells</dc:subject>
      <dc:description>The skin is the largest organ of the human body, and its dysfunction is related to&#xd;
many diseases. There is a need to find new potential effective therapies for some&#xd;
skin conditions such as inflammatory diseases, wound healing, or hair restoration.&#xd;
Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential&#xd;
opportunity in the treatment of skin disease. Thus, the objective of this review is to&#xd;
evaluate the uses of MSC-CM for treating skin diseases in both animal and human&#xd;
models. A systematic review was conducted regarding the use of MSC-CM for treating&#xd;
skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in&#xd;
wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15),&#xd;
skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from&#xd;
different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood.&#xd;
MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or&#xd;
intralesionally injected or topically applied. MSC-CM was used in both animals and&#xd;
humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic&#xd;
dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased&#xd;
hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a&#xd;
promising therapy for skin conditions. Further studies are needed to corroborate safety&#xd;
and effectiveness and to standardize CM manufacturing.</dc:description>
      <dc:date>2021-09-30T12:29:41Z</dc:date>
      <dc:date>2021-09-30T12:29:41Z</dc:date>
      <dc:date>2021-07-23</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Montero-Vilchez T... [et al.] (2021) Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review. Front. Cell Dev. Biol. 9:654210. doi: [10.3389/fcell.2021.654210]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/70563</dc:identifier>
      <dc:identifier>10.3389/fcell.2021.654210</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>Frontiers Research Foundation</dc:publisher>
   </ow:Publication>
</rdf:RDF>