Differential inflammatory response of men and women subjected to an acute resistance exercise Aragón Vela, Jerónimo Fontana Gallego, Luis Casuso Pérez, Rafael Antonio Plaza Díaz, Julio Rodríguez Huertas, Jesús Francisco IL6 Serum interleukins Inflammatory response Sex differences Strength exercise This work was possible thanks to the funding that Junta de Andaluca awarded to the research group CTS454. J Arag?onVela was awarded a Formaci?on de Profesorado Universitario (FPU) fellowship from the Ministry of Education, Culture and Sports of the Spanish Government (AP20121867) . This paper was part of Jer?onimo Arag?on Vela's PhD thesis, performed within the "Nutrition and Food Sciences Program" at the University of Granada, Spain. We thank Nutraceutical Trans-lations for English language editing of this manuscript. Background: The purpose of this study was to investigate the inflammatory response, lipid peroxidation and muscle damage in men and women athletes subjected to an acute resistance exercise. Methods: Twenty college athletes (10 men and 10 women) performed a half-squat exercise consisting of five incremental intensities: 20%, 40%, 60%, 80% and 100% of the onerepetition maximum. Blood samples were collected at rest, 15 min and 24 h post-test. The concentration of lipid peroxidation markers and the activities of a skeletal muscle damage marker and a cardiac muscle damage marker were determined in serum. Serum aactin was measured as a marker of sarcomere damage. Serum levels of interleukin-6, interleukin-10, and tumor necrosis factor alpha were determined to assess the inflammatory response. Results: Interleukin-6 levels were higher at 24 h post-test than at rest and 15 min post-test in men (p < 0.05). Moreover, men showed significantly higher hydroperoxide levels in response to resistance exercise at 24 h post-test than at 15 min post-test (p < 0.05). No differences were found in muscle damage parameters regardless of sex or the time point of the test. No differences regarding the studied variables were found when comparing among different time points in women. Conclusion: Our results show a larger influence of half-squat exercises on the release of IL6 and on lipid peroxidation in men than in women at equivalent workloads. 2021-09-30T08:35:10Z 2021-09-30T08:35:10Z 2021-06-14 info:eu-repo/semantics/article Jerónimo Aragón-Vela... [et al.]. Differential inflammatory response of men and women subjected to an acute resistance exercise, Biomedical Journal, Volume 44, Issue 3, 2021, Pages 338-345, ISSN 2319-4170, [https://doi.org/10.1016/j.bj.2020.02.005] http://hdl.handle.net/10481/70552 10.1016/j.bj.2020.02.005 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España Elsevier